gene 2,239 words KG: GABRA5 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsonsstate:published
Contents

GABRA5 Gene

🧬 Gene Info
Gene SymbolGABRA5
Full NameGamma-Aminobutyric Acid Type A Receptor Alpha5 Subunit
Chromosome15q12
Protein TypeReceptor
Functionencodes a 456-amino acid protein that forms the distinctive pentameric structure of the GABA-A receptor.
Subcellular Localizationextrasynaptic locations in the hippocampus and cortex, making them uniquely positioned to modulate neuronal excitability
Molecular Weight~52 kDa
Amino Acids456 aa
Exons9
UniProt IDP31644
NCBI Gene ID2568
Ensembl IDENSG00000118190
OMIM137142
GeneCardsGABRA5
Human Protein AtlasGABRA5
Associated DiseasesALS, Bipolar, Depression, Ms, Schizophrenia
InteractionsTRPM2, GABRG2, GABRA1
KG Connections73 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.41
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Packard Center for ALS Research
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
GRIN2B — NMDA Receptor Subunit 2B
gene · KG edge: associated_with
GABRA1 Gene
gene · KG edge: activates
DRD1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

GABRA5 associated_with POLG
GABRA5 associated_with TRPM2
GABRA5 associated_with GRM3
GABRA5 associated_with DAO
GABRA5 associated_with NRG1
GABRA5 associated_with GRIN2B
GABRA5 associated_with RGS4
GABRA5 associated_with NCAM1
GABRA5 associated_with DISC1
GABRA5 associated_with FKBP5