protein

CNTN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CNTN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

0Hypotheses

0Analyses

35Outgoing

13Incoming

Summary

Page for CNTN1 Protein

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🔬 Protein Info

Gene Symbol	CNTN1
Full Name	Contactin 1
Aliases	CNTN, F3, Contactin-1, Neural Cell Surface Protein F3
Chromosome	12q11-q21
Function	Contactin 1 is a GPI-anchored neuronal cell adhesion molecule with six immunoglobulin-like domains and four fibronectin type III repeats.
Primary Expression	the nervous system and is essential for the formation and maintenance of neural circuits
Molecular Weight	160 kDa
Pathways	Mtor, Nf-Κb
UniProt ID	Q12866
NCBI Gene ID	1277
Ensembl ID	ENSG00000124244
OMIM	600430
GeneCards	CNTN1
Human Protein Atlas	CNTN1
Associated Diseases	neurodegeneration
Interactions	NGF, ESR1, GABRB3, MAPT, PSEN1, SCARB2
KG Connections	48 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CNTN1 — AlphaFold Q12866 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CNTN1(["CNTN1"])
    Tumor["Tumor"]
    Cancer["Cancer"]
    ALS["ALS"]
    Carcinoma["Carcinoma"]
    Als["Als"]
    NGF["NGF"]
    Mtor["Mtor"]
    Nf__b["Nf-Kappab"]
    ERK["ERK"]
    Epithelial["Epithelial"]
    T_Cell["T Cell"]
    AKT["AKT"]
    NF__B["NF-KappaB"]
    AND["AND"]
    MTOR["MTOR"]
    CNTN1 -->|"activates"| Tumor
    CNTN1 -->|"activates"| Cancer
    CNTN1 -->|"activates"| ALS
    CNTN1 -->|"activates"| Carcinoma
    CNTN1 -->|"therapeutic_tar"| Als
    CNTN1 -->|"therapeutic_tar"| Cancer
    CNTN1 -->|"biomarker_for"| NGF
    CNTN1 -->|"activates"| Mtor
    CNTN1 -->|"activates"| Nf__b
    CNTN1 -->|"therapeutic_tar"| ERK
    CNTN1 -.-|"associated"| NGF
    CNTN1 -->|"therapeutic_tar"| Nf__b
    CNTN1 -->|"therapeutic_tar"| Mtor
    CNTN1 -->|"therapeutic_tar"| Epithelial
    CNTN1 -->|"therapeutic_tar"| T_Cell
    AKT -->|"activates"| CNTN1
    NF__B -->|"activates"| CNTN1
    NGF -.-|"associated"| CNTN1
    AND -.-|"associated"| CNTN1
    MTOR -->|"activates"| CNTN1
    style CNTN1 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (36)

Target	Relation	Type	Str
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
ALS	activates	disease	0.65
Carcinoma	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
NGF	biomarker_for	entity	0.60
NGF	associated_with	gene	0.60
Rb	therapeutic_target	protein	0.60
Hif-1	therapeutic_target	protein	0.60
NGF	interacts_with	gene	0.60
ESR1	interacts_with	gene	0.60
GABRB3	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
SCARB2	interacts_with	gene	0.60
TFAM	interacts_with	gene	0.60
TREM2	interacts_with	gene	0.60
UCHL1	interacts_with	gene	0.60
Mtor	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
ERK	therapeutic_target	gene	0.60
Nf-Κb	therapeutic_target	pathway	0.60
Mtor	therapeutic_target	pathway	0.60
Epithelial	therapeutic_target	cell_type	0.60
T Cell	therapeutic_target	cell_type	0.60
HIF-1Α	activates	gene	0.60
AND	associated_with	gene	0.60
Ngf	biomarker_for	protein	0.60
Akt	therapeutic_target	protein	0.60
Ras	therapeutic_target	protein	0.60
App	associated_with	protein	0.60
oxidative stress response	participates_in	pathway	0.60
DNA	interacts_with	gene	0.60
T Cell	expressed_in	cell_type	0.55

Incoming (13)

Source	Relation	Type	Str
AKT	activates	gene	0.60
NGF	associated_with	gene	0.60
MTOR	activates	gene	0.60
A2M	interacts_with	gene	0.60
BCHE	interacts_with	gene	0.60
CHRFAM7A	interacts_with	gene	0.60
NF-ΚB	activates	gene	0.60
AND	associated_with	gene	0.60
HIF	activates	gene	0.60
ERK	activates	gene	0.60
HIF-1Α	activates	gene	0.60
CANCER	activates	gene	0.50
ERK	inhibits	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CNTN1

Understanding Entity Pages

Summary

Wiki Pages (16)

CNTN1 Gene

CNTN5 — Contactin 5

CNTN6 — Contactin 6

CNTN4 — Contactin 4

CNTN3 — Contactin 3

TNR Gene — Tenascin R

GABRB3 Gene

Paranodal Dysfunction in Neurodegeneration

Nodes of Ranvier

Contactin-1 - Biomarker for Peripheral Neuropathy

GABRB3

NFASC Protein

PTPRG Protein

CNTN1 Protein