gene

UCHL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UCHL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

183Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

Summary

UCHL1 is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, interacts with, activates. Associated with ALS, Als, Alzheimer. Connected to 72 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	UCHL1
Chromosome	4p14
Protein Type	Enzyme
Function	is a highly abundant neuronal deubiquitinating enzyme that constitutes 1-5% of total brain protein.
Primary Expression	Cytoplasmic, enriched in axons and synaptic terminals
Subcellular Localization	Cytoplasmic, enriched in axons and synaptic terminals
Molecular Weight	24.8 kDa
Amino Acids	223 aa
Exons	9
Pathways	Angiogenesis, Autophagy, Ferroptosis, Glycolysis, Neural Stem Cell Maintenance
GeneCards	UCHL1
Human Protein Atlas	UCHL1
Gene location	4p14 (human)
Protein length	230 amino acids
Molecular weight	24,824 Da
Associated Diseases	Ataxia, Ms, Neurodegenerative Diseases, Traumatic Brain Injury, neurodegeneration
Interactions	GFAP, TMEM119, NFL, NRF2, KEAP1, UBIQUITIN
KG Connections	183 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    UCHL1["<b>UCHL1</b>"]
    Neurodegeneration{"Neurodegeneration"}
    UCHL1 -->|"biomarker for"| Neurodegeneration
    Dementia{"Dementia"}
    UCHL1 -->|"biomarker for"| Dementia
    Inflammation{"Inflammation"}
    UCHL1 -->|"biomarker for"| Inflammation
    Als{"Als"}
    UCHL1 -->|"biomarker for"| Als
    Neuroinflammation{"Neuroinflammation"}
    UCHL1 -->|"biomarker for"| Neuroinflammation
    Alzheimer{"Alzheimer"}
    UCHL1 -->|"biomarker for"| Alzheimer
    Traumatic_Brain_Injury{"Traumatic Brain Injury"}
    UCHL1 -->|"biomarker for"| Traumatic_Brain_Injury
    Parkinson{"Parkinson"}
    UCHL1 -->|"biomarker for"| Parkinson
    Ms{"Ms"}
    UCHL1 -->|"inhibits"| Ms
    ALS{"ALS"}
    UCHL1 -->|"biomarker for"| ALS
    GFAP["GFAP"]
    UCHL1 -->|"interacts with"| GFAP
    TMEM119["TMEM119"]
    UCHL1 -->|"interacts with"| TMEM119
    TMEM119 -->|"interacts with"| UCHL1
    GFAP -->|"interacts with"| UCHL1
    NFL["NFL"]
    NFL -->|"interacts with"| UCHL1
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"biomarker for"| UCHL1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"biomarker for"| UCHL1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"biomarker for"| UCHL1
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"biomarker for"| UCHL1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"biomarker for"| UCHL1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"biomarker for"| UCHL1
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"biomarker for"| UCHL1
    BRAIN_INJURY["BRAIN INJURY"]
    BRAIN_INJURY -->|"biomarker for"| UCHL1
    PARKINSON["PARKINSON"]
    PARKINSON -->|"biomarker for"| UCHL1
    style UCHL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (122)

Target	Relation	Type	Str
Neural Stem Cell Maintenance	involved_in	process	0.85
blood-brain barrier integrity	associated_with	process	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
VEGFA	upregulates	protein	0.80
Neurodegeneration	biomarker_for	disease	0.65
Dementia	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Traumatic Brain Injury	biomarker_for	disease	0.65
Parkinson	biomarker_for	disease	0.65
Ms	inhibits	disease	0.65
ALS	biomarker_for	disease	0.65
Ataxia	associated_with	disease	0.65
Traumatic Brain Injury	implicated_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Als	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Tumor	inhibits	disease	0.65
Ms	implicated_in	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
ALS	activates	disease	0.65
ALS	protects_against	disease	0.65
Parkinson	protects_against	disease	0.65
GFAP	interacts_with	gene	0.60
TMEM119	interacts_with	gene	0.60
NFL	interacts_with	gene	0.60
NRF2	activates	gene	0.60
KEAP1	activates	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
APP	implicated_in	gene	0.60
UBIQUITIN	activates	gene	0.60
UBIQUITIN	regulates	gene	0.60
E2F1	regulates	gene	0.60
ANGPT1	activates	gene	0.60
Hif-1	activates	protein	0.60
Vegf	activates	protein	0.60
Rb	activates	protein	0.60
neuroinflammation	interacts_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
DNAJC6	regulates	gene	0.60
CAT	protects_against	gene	0.60
LRRK2	regulates	gene	0.60
VPS35	inhibits	gene	0.60
neurodegeneration	expressed_in	disease	0.60
USP27X	associated_with	gene	0.60

Incoming (61)

Source	Relation	Type	Str
TMEM119	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
NFL	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
UBIQUITIN	regulates	gene	0.60
CD68	activates	gene	0.60
MYC	regulates	gene	0.60
ANGPT1	activates	gene	0.60
VEGFA	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
VPS35	regulates	gene	0.60
A2M	interacts_with	gene	0.60
BCHE	interacts_with	gene	0.60
CHRFAM7A	interacts_with	gene	0.60
CNTN1	interacts_with	gene	0.60
ESR1	interacts_with	gene	0.60
GABRB3	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
SCARB2	interacts_with	gene	0.60
TFAM	interacts_with	gene	0.60
TREM2	interacts_with	gene	0.60
LRRK2	inhibits	gene	0.60
SNCA	inhibits	gene	0.60
MMP9	interacts_with	gene	0.60
ATXN3	interacts_with	gene	0.60
FBXO7	activates	gene	0.60
LRRK2	activates	gene	0.60
PINK1	activates	gene	0.60
PTEN	activates	gene	0.60
SNCA	activates	gene	0.60
C3	expressed_in	gene	0.60
CLU	expressed_in	gene	0.60
ASTROCYTES	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
MICROGLIA	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
NEURODEGENERATIVE DISEASES	biomarker_for	gene	0.60
PARKINSON'S DISEASE	biomarker_for	gene	0.60
DEMENTIA	biomarker_for	gene	0.60
BRAIN INJURY	biomarker_for	gene	0.60
PARKINSON	biomarker_for	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
NEURODEGENERATIVE DISORDERS	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
NEUROINFLAMMATION	biomarker_for	gene	0.60
AUTOPHAGY	activates	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
BRAIN INJURY	implicated_in	gene	0.60
AND	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

UCHL1

Understanding Entity Pages

Summary

Wiki Pages (21)

Ubiquitin C-terminal Hydrolase L1 (UCH-L1)

cbs-psp-daily-action-plan

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

Cerebrospinal Fluid (CSF) Biomarkers Overview

proteasome-ubiquitin-system-dysfunction-parkinsons

ubiquitin-proteasome-dysfunction-neurodegeneration

UCHL1 (PARK5) Pathway in Parkinson's Disease

AIFM1 Gene

Ubiquitin-Proteasome System Dysfunction in Neurodegeneration

Ubiquitin-Proteasome System Dysfunction in Parkinson's Disease

Neurons

Parkinson's Disease Mechanisms

Alpha-Synuclein Aggregation Pathway in Parkinson's Disease

snca-protein

CDR1 Gene

Section 102: Proteostasis Network Dysregulation in CBS/PSP

Proteostasis Therapy CBS PSP

Ubiquitin-Proteasome System Dysfunction in Alzheimer's Disease

Senescent Cell Clearance in Neurodegeneration

Proteostasis and ERAD Pathway in Neurodegeneration