protein

GRIA1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRIA1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The GRIA1 protein (GluA1) is a critical subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) type glutamate receptor, the primary mediator of fast excitatory synaptic transmission in the mammalian brain.

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🔬 Protein Info

Gene Symbol	GRIA1PROTEIN
Protein Type	Receptor
Function	is a critical subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) type glutamate receptor, the primary mediator of fast excitatory synaptic transmission in the mammalian brain.
Subcellular Localization	** \| Postsynaptic membrane, dendritic spines
Molecular Weight	103 kDa
Amino Acids	906 aa
GeneCards	GRIA1PROTEIN
Human Protein Atlas	GRIA1PROTEIN
Approach	Agent/Strategy
AMPA Antagonists	Perampanel
AMPA Modulators	CX-516 (Ampalex)
Ampakines	CX-717, IDRA-21
Gene Therapy	AAV-GRIA1
Kinase Inhibitors	CaMKII inhibitors
Zinc Modulation	Zinc compounds
Associated Diseases	Aging, Als, Alzheimer, Autism, Bipolar, Cancer
Interactions	ADRA1A, HRH1, GRIN1, HCRTR1, SNAP25, ACTG1
KG Connections	193 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

gria1-protein

protein · 2371 words

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Pathway Diagram

graph TD
    GRIA1PROTEIN["GRIA1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GRIA1PROTEIN -->|"implicated_in"| neurodegeneration
    style GRIA1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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No papers found