| Gene Symbol | GRIA1PROTEIN |
| Protein Type | Receptor |
| Function | is a critical subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) type glutamate receptor, the primary mediator of fast excitatory synaptic transmission in the mammalian brain. |
| Subcellular Localization | ** | Postsynaptic membrane, dendritic spines |
| Molecular Weight | 103 kDa |
| Amino Acids | 906 aa |
| GeneCards | GRIA1PROTEIN |
| Human Protein Atlas | GRIA1PROTEIN |
| Approach | Agent/Strategy |
| AMPA Antagonists | Perampanel |
| AMPA Modulators | CX-516 (Ampalex) |
| Ampakines | CX-717, IDRA-21 |
| Gene Therapy | AAV-GRIA1 |
| Kinase Inhibitors | CaMKII inhibitors |
| Zinc Modulation | Zinc compounds |
| Associated Diseases | Aging, Als, Alzheimer, Autism, Bipolar, Cancer |
| Interactions | ADRA1A, HRH1, GRIN1, HCRTR1, SNAP25, ACTG1 |
| KG Connections | 193 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |