gene

GSN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

14Outgoing

3Incoming

Summary

Page for GSN Gene

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🧬 Gene Info

Gene Symbol	GSN
Full Name	Gelsolin
Chromosome	9q34.11
Function	is a calcium-activated actin-binding protein that belongs to the villin/gelsolin superfamily.
Primary Expression	most cell types throughout the body:
Molecular Weight	~82 kDa
Amino Acids	755 aa
Pathways	Synaptic Plasticity
UniProt ID	P06396
NCBI Gene ID	2694
Ensembl ID	ENSG00000148180
OMIM	137350
GeneCards	GSN
Human Protein Atlas	GSN
Protein Size	755 amino acids
Associated Diseases	neurodegeneration
Interactions	ANG, Actin, NLRP3, AND
KG Connections	17 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GSN — AlphaFold P06396 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GSN["<b>GSN</b>"]
    Als{"Als"}
    GSN -->|"expressed in"| Als
    Schizophrenia{"Schizophrenia"}
    GSN -->|"expressed in"| Schizophrenia
    SNAP25["SNAP25"]
    GSN -->|"expressed in"| SNAP25
    PPP1R1B["PPP1R1B"]
    GSN -->|"regulates"| PPP1R1B
    SNAP29["SNAP29"]
    GSN -->|"expressed in"| SNAP29
    CDK5["CDK5"]
    GSN -->|"regulates"| CDK5
    Synaptic_Plasticity(["Synaptic Plasticity"])
    GSN -->|"regulates"| Synaptic_Plasticity
    Immune_Response(["Immune Response"])
    GSN -->|"expressed in"| Immune_Response
    neurodegeneration["neurodegeneration"]
    GSN -->|"implicated in"| neurodegeneration
    style GSN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (14)

Target	Relation	Type	Str
Als	expressed_in	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Sepsis	activates	disease	0.65
Rheumatoid Arthritis	activates	disease	0.65
SNAP25	expressed_in	gene	0.60
PPP1R1B	regulates	gene	0.60
SNAP29	expressed_in	gene	0.60
CDK5	regulates	gene	0.60
ANG	activates	gene	0.60
Synaptic Plasticity	regulates	pathway	0.60
Immune Response	expressed_in	pathway	0.60
Nlrp3 Inflammasome	activates	pathway	0.60
Inflammasome	activates	pathway	0.60
Actin	activates	protein	0.60

Incoming (3)

Source	Relation	Type	Str
NLRP3	activates	gene	0.60
MITOCHONDRIA	contributes_to	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GSN

Understanding Entity Pages

Summary

Wiki Pages (8)

GSN Gene

Ludwig Maximilian University of Munich (LMU)

Knowledge Gap: Blood-Based Biomarkers for Early Neurodegeneration Detection

Protein Rankings

Gelsolin Protein

PPP1R1B Gene