Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HIP1R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HIP1R encodes a critical protein involved in clathrin-mediated endocytosis, actin cytoskeleton dynamics, and cellular trafficking. Implicated in Huntington's disease, Alzheimer's disease, and Parkinson's disease through its interactions with huntingtin and role in synaptic function.
| Gene Symbol | HIP1R |
| Aliases | HIP1R, SLAIN2, B murine sarcoma virus CT10 |
| Chromosome | 22q13.31 |
| Protein Type | Clathrin coat component, Actin-binding protein |
| Function | encodes a critical protein involved in clathrin-mediated endocytosis, actin cytoskeleton organization, and cellular trafficking. |
| Primary Expression | the brain, particularly in neurons of the cortex, hippocampus, and cerebellum, where it performs essential roles in synaptic vesicle trafficking, rece |
| Molecular Weight | ~116 kDa |
| Amino Acids | 1031 aa |
| Ensembl ID | ENSG00000128284 |
| GeneCards | HIP1R |
| Human Protein Atlas | HIP1R |
| Gene Name | Huntingtin Interacting Protein 1-Related |
| Protein Size | 1031 amino acids |
| Stage | HIP1R Function |
| Initiation | Recruitment to plasma membrane sites |
| Associated Diseases | Als |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HIP1R["<b>HIP1R</b>"]
Als{"Als"}
HIP1R -->|"associated with"| Als
Cardiac{"Cardiac"}
HIP1R -->|"regulates"| Cardiac
neurodegeneration["neurodegeneration"]
HIP1R -->|"implicated in"| neurodegeneration
RYR2["RYR2"]
RYR2 -->|"regulates"| HIP1R
SCN1A["SCN1A"]
SCN1A -->|"regulates"| HIP1R
ROBO1["ROBO1"]
ROBO1 -->|"associated with"| HIP1R
GAD2["GAD2"]
GAD2 -->|"regulates"| HIP1R
PIK3CB["PIK3CB"]
PIK3CB -->|"regulates"| HIP1R
NOS1["NOS1"]
NOS1 -->|"regulates"| HIP1R
CFTR["CFTR"]
CFTR -->|"regulates"| HIP1R
EPHB4["EPHB4"]
EPHB4 -->|"associated with"| HIP1R
MMP2["MMP2"]
MMP2 -->|"associated with"| HIP1R
style HIP1R fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||