gene

SCN1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCN1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

171Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

SCN1A is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, causes. Associated with Aging, Als, Autism. Connected to 99 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSCN1A
Chromosome2q24.3
Primary ExpressionBrain (neurons, particularly GABAergic interneurons), heart
Molecular Weight226 kDa
Amino Acids2000 aa
UniProt IDP35499
NCBI Gene ID6335
Ensembl IDENSG00000144285
OMIM182389
GeneCardsSCN1A
Human Protein AtlasSCN1A
Genomic Coordinateschr2:165,990,000-166,100,000 (GRCh38)
Gene Length~190 kb
Number of Exons26 coding exons
Transcript Length~7.2 kb coding sequence
Associated DiseasesAls, Cancer, Epilepsy
InteractionsSNAP25, PVALB, GENES
KG Connections171 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: SCN1A — AlphaFold P35499 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

SCN1A

gene · 889 words

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

Ion Channel Dysfunction in Huntington's Disease

mechanism · 3782 words

Ion Channel Dysfunction in Alzheimer's Disease

mechanism · 3308 words

Ion Channel Dysfunction in Frontotemporal Dementia

mechanism · 3283 words

ion-channel-dysfunction-disease-comparison

mechanism · 3208 words

Pathway Diagram

graph TD
    SCN1A["SCN1A"]
    SCN1A -->|"target for"| Aging["Aging"]
    SCN1A -->|"target for"| Als["Als"]
    SCN1A -->|"target for"| Neuroinflammation["Neuroinflammation"]
    SCN1A -->|"target for"| Epilepsy["Epilepsy"]
    SCN1A -->|"target for"| Autism["Autism"]
    SCN1A -->|"target for"| Ms["Ms"]
    SCN1A -->|"target for"| Inflammation["Inflammation"]
    SCN1A -->|"regulates"| Cardiac["Cardiac"]
    SCN1A -->|"target for"| MTOR["MTOR"]
    SCN1A -->|"target for"| RELN["RELN"]
    DHX9["DHX9"] -->|"target for"| SCN1A
    KCNT1["KCNT1"] -->|"target for"| SCN1A
    KCNQ2["KCNQ2"] -->|"target for"| SCN1A
    GENES["GENES"] -->|"target for"| SCN1A
    RYR2["RYR2"] -->|"regulates"| SCN1A
    KCNMA1["KCNMA1"] -->|"causes"| SCN1A
    KCNQ1["KCNQ1"] -->|"causes"| SCN1A
    PIEZO1["PIEZO1"] -->|"causes"| SCN1A
    CFTR["CFTR"] -->|"causes"| SCN1A

Outgoing (96)

TargetRelationTypeStr
Agingtherapeutic_targetdisease0.75
Alstherapeutic_targetdisease0.75
Epigenetictherapeutic_targetpathway0.70
Cancerassociated_withdisease0.65
Neuroinflammationtherapeutic_targetdisease0.65

Incoming (75)

SourceRelationTypeStr
PIEZO1associated_withgene0.60
KCNK2associated_withgene0.60
SCN5Aassociated_withgene0.60
TRPM7associated_withgene0.60
CACNA1Bassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found