Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SCN1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SCN1A is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, causes. Associated with Aging, Als, Autism. Connected to 99 entities in the SciDEX knowledge graph.
| Gene Symbol | SCN1A |
| Chromosome | 2q24.3 |
| Primary Expression | Brain (neurons, particularly GABAergic interneurons), heart |
| Molecular Weight | 226 kDa |
| Amino Acids | 2000 aa |
| UniProt ID | P35499 |
| NCBI Gene ID | 6335 |
| Ensembl ID | ENSG00000144285 |
| OMIM | 182389 |
| GeneCards | SCN1A |
| Human Protein Atlas | SCN1A |
| Genomic Coordinates | chr2:165,990,000-166,100,000 (GRCh38) |
| Gene Length | ~190 kb |
| Number of Exons | 26 coding exons |
| Transcript Length | ~7.2 kb coding sequence |
| Associated Diseases | Als, Cancer, Epilepsy |
| Interactions | SNAP25, PVALB, GENES |
| KG Connections | 171 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SCN1A["SCN1A"]
SCN1A -->|"target for"| Aging["Aging"]
SCN1A -->|"target for"| Als["Als"]
SCN1A -->|"target for"| Neuroinflammation["Neuroinflammation"]
SCN1A -->|"target for"| Epilepsy["Epilepsy"]
SCN1A -->|"target for"| Autism["Autism"]
SCN1A -->|"target for"| Ms["Ms"]
SCN1A -->|"target for"| Inflammation["Inflammation"]
SCN1A -->|"regulates"| Cardiac["Cardiac"]
SCN1A -->|"target for"| MTOR["MTOR"]
SCN1A -->|"target for"| RELN["RELN"]
DHX9["DHX9"] -->|"target for"| SCN1A
KCNT1["KCNT1"] -->|"target for"| SCN1A
KCNQ2["KCNQ2"] -->|"target for"| SCN1A
GENES["GENES"] -->|"target for"| SCN1A
RYR2["RYR2"] -->|"regulates"| SCN1A
KCNMA1["KCNMA1"] -->|"causes"| SCN1A
KCNQ1["KCNQ1"] -->|"causes"| SCN1A
PIEZO1["PIEZO1"] -->|"causes"| SCN1A
CFTR["CFTR"] -->|"causes"| SCN1A| Target | Relation | Type | Str |
|---|---|---|---|
| Aging | therapeutic_target | disease | 0.75 |
| Als | therapeutic_target | disease | 0.75 |
| Epigenetic | therapeutic_target | pathway | 0.70 |
| Cancer | associated_with | disease | 0.65 |
| Neuroinflammation | therapeutic_target | disease | 0.65 |
| Epilepsy | therapeutic_target | disease | 0.65 |
| Autism | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Cardiac | regulates | disease | 0.65 |
| Epilepsy | associated_with | disease | 0.65 |
| TRPV4 | associated_with | gene | 0.60 |
| CACNA1B | associated_with | gene | 0.60 |
| SCNN1A | associated_with | gene | 0.60 |
| CFTR | associated_with | gene | 0.60 |
| PIEZO2 | associated_with | gene | 0.60 |
| TRPA1 | associated_with | gene | 0.60 |
| KCNMA1 | associated_with | gene | 0.60 |
| TRPV1 | associated_with | gene | 0.60 |
| KCNN4 | associated_with | gene | 0.60 |
| KCNQ1 | associated_with | gene | 0.60 |
| CACNA1C | associated_with | gene | 0.60 |
| KCNK2 | associated_with | gene | 0.60 |
| Axon Guidance | associated_with | pathway | 0.60 |
| MTOR | therapeutic_target | gene | 0.60 |
| RELN | therapeutic_target | gene | 0.60 |
| STXBP1 | therapeutic_target | gene | 0.60 |
| SYNGAP1 | therapeutic_target | gene | 0.60 |
| ROBO1 | associated_with | gene | 0.60 |
| GAD2 | regulates | gene | 0.60 |
| PIK3CB | regulates | gene | 0.60 |
| NOS1 | regulates | gene | 0.60 |
| CFTR | regulates | gene | 0.60 |
| EPHB4 | associated_with | gene | 0.60 |
| MMP2 | associated_with | gene | 0.60 |
| HIP1R | regulates | gene | 0.60 |
| TRPA1 | causes | gene | 0.60 |
| KCNN4 | causes | gene | 0.60 |
| PIEZO2 | causes | gene | 0.60 |
| SCN5A | causes | gene | 0.60 |
| TRPV4 | causes | gene | 0.60 |
| SCNN1A | causes | gene | 0.60 |
| TRPV1 | causes | gene | 0.60 |
| KCNK2 | causes | gene | 0.60 |
| CACNA1B | causes | gene | 0.60 |
| CACNA1C | causes | gene | 0.60 |
| TRPM7 | causes | gene | 0.60 |
| SCN5A | associated_with | entity | 0.60 |
| TRPM7 | associated_with | entity | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PIEZO1 | associated_with | gene | 0.60 |
| KCNK2 | associated_with | gene | 0.60 |
| SCN5A | associated_with | gene | 0.60 |
| TRPM7 | associated_with | gene | 0.60 |
| CACNA1B | associated_with | gene | 0.60 |
| CACNA1C | associated_with | gene | 0.60 |
| CFTR | associated_with | gene | 0.60 |
| TRPV4 | associated_with | gene | 0.60 |
| KCNQ1 | associated_with | gene | 0.60 |
| TRPA1 | associated_with | gene | 0.60 |
| TRPV1 | associated_with | gene | 0.60 |
| KCNMA1 | associated_with | gene | 0.60 |
| DHX9 | therapeutic_target | gene | 0.60 |
| KCNT1 | therapeutic_target | gene | 0.60 |
| KCNQ2 | therapeutic_target | gene | 0.60 |
| RYR2 | regulates | gene | 0.60 |
| KCNMA1 | causes | gene | 0.60 |
| KCNQ1 | causes | gene | 0.60 |
| PIEZO1 | causes | gene | 0.60 |
| CFTR | causes | gene | 0.60 |
| KCNK2 | causes | gene | 0.60 |
| TRPV4 | causes | gene | 0.60 |
| CACNA1B | causes | gene | 0.60 |
| CACNA1C | causes | gene | 0.60 |
| MTOR | therapeutic_target | gene | 0.60 |
| RELN | therapeutic_target | gene | 0.60 |
| STXBP1 | therapeutic_target | gene | 0.60 |
| KCNN4 | associated_with | entity | 0.60 |
| PIEZO2 | associated_with | entity | 0.60 |
| TRPA1 | causes | gene | 0.60 |
| TRPV1 | causes | gene | 0.60 |
| PIEZO2 | causes | gene | 0.60 |
| SCN5A | causes | gene | 0.60 |
| SCNN1A | causes | gene | 0.60 |
| PVALB | associated_with | gene | 0.60 |
| SNAP25 | associated_with | gene | 0.60 |
| KCNN4 | causes | gene | 0.60 |
| PVALB | interacts_with | gene | 0.60 |
| CDKL5 | associated_with | gene | 0.60 |
| HCN1 | associated_with | gene | 0.60 |
| KCNQ2 | associated_with | gene | 0.60 |
| PLCB1 | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| HIPPO | associated_with | gene | 0.60 |
| TCR | associated_with | gene | 0.60 |
| AXON | associated_with | gene | 0.60 |
| EPILEPSY | therapeutic_target | gene | 0.60 |
| NEUROINFLAMMATION | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||