Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GAD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GAD2 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, implicated in. Associated with Als, Cardiac, Diabetes. Connected to 17 entities in the SciDEX knowledge graph.
| Gene Symbol | GAD2 |
| Full Name | Glutamate Decarboxylase 2 |
| Chromosome | 10p12.1 |
| Protein Type | Receptor |
| Function | It plays critical roles in ciliary signaling, neuronal migration, and synaptic function. |
| Primary Expression | regions affected in Parkinson disease |
| UniProt ID | Q96S44 |
| NCBI Gene ID | 2572 |
| Ensembl ID | ENSG00000136750 |
| OMIM | 300036 |
| GeneCards | GAD2 |
| Human Protein Atlas | GAD2 |
| Associated Diseases | Als |
| Interactions | GAD1, PVALB, TRKB, DEPRESSION, Ras |
| KG Connections | 65 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GAD2["<b>GAD2</b>"]
Als{"Als"}
GAD2 -->|"associated with"| Als
Cardiac{"Cardiac"}
GAD2 -->|"regulates"| Cardiac
Diabetes{"Diabetes"}
GAD2 -->|"regulates"| Diabetes
GAD2 -->|"regulates"| Als
PIK3CB["PIK3CB"]
GAD2 -->|"regulates"| PIK3CB
NOS1["NOS1"]
GAD2 -->|"regulates"| NOS1
CFTR["CFTR"]
GAD2 -->|"regulates"| CFTR
EPHB4["EPHB4"]
GAD2 -->|"associated with"| EPHB4
MMP2["MMP2"]
GAD2 -->|"associated with"| MMP2
HIP1R["HIP1R"]
GAD2 -->|"regulates"| HIP1R
USH1C["USH1C"]
GAD2 -->|"regulates"| USH1C
neurodegeneration["neurodegeneration"]
GAD2 -->|"implicated in"| neurodegeneration
RYR2["RYR2"]
RYR2 -->|"regulates"| GAD2
SCN1A["SCN1A"]
SCN1A -->|"regulates"| GAD2
ROBO1["ROBO1"]
ROBO1 -->|"associated with"| GAD2
ABCD3["ABCD3"]
ABCD3 -->|"regulates"| GAD2
HNF4A["HNF4A"]
HNF4A -->|"expressed in"| GAD2
style GAD2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | associated_with | disease | 0.65 |
| Cardiac | regulates | disease | 0.65 |
| Diabetes | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Depression | inhibits | disease | 0.65 |
| PIK3CB | regulates | gene | 0.60 |
| NOS1 | regulates | gene | 0.60 |
| CFTR | regulates | gene | 0.60 |
| EPHB4 | associated_with | gene | 0.60 |
| MMP2 | associated_with | gene | 0.60 |
| HIP1R | regulates | gene | 0.60 |
| USH1C | regulates | gene | 0.60 |
| TP53 | therapeutic_target | gene | 0.60 |
| STAT3 | therapeutic_target | gene | 0.60 |
| MAPK8 | therapeutic_target | gene | 0.60 |
| BDNF | regulates | gene | 0.60 |
| GAD1 | inhibits | gene | 0.60 |
| PVALB | inhibits | gene | 0.60 |
| SST | regulates | gene | 0.60 |
| TRKB | inhibits | gene | 0.60 |
| NPY | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.60 |
| ACHE | therapeutic_target | gene | 0.60 |
| Lipid Metabolism | therapeutic_target | pathway | 0.60 |
| Synaptic Plasticity | therapeutic_target | pathway | 0.60 |
| Mapk | therapeutic_target | pathway | 0.60 |
| GABA | regulates | gene | 0.60 |
| Interneuron | regulates | cell_type | 0.60 |
| Neuron | regulates | cell_type | 0.60 |
| DEPRESSION | inhibits | gene | 0.60 |
| Bdnf | regulates | protein | 0.60 |
| Ras | inhibits | protein | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| Amygdala | expressed_in | brain_region | 0.55 |
| inhibitory neurons | expressed_in | cell_type | 0.55 |
| Cortex | expressed_in | brain_region | 0.55 |
| Interneuron | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| INTERNEURONS | regulates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RYR2 | regulates | gene | 0.60 |
| SCN1A | regulates | gene | 0.60 |
| ROBO1 | associated_with | gene | 0.60 |
| ABCD3 | regulates | gene | 0.60 |
| HNF4A | expressed_in | gene | 0.60 |
| PPARG | therapeutic_target | gene | 0.60 |
| MAOA | therapeutic_target | gene | 0.60 |
| PRKCA | therapeutic_target | gene | 0.60 |
| EGFR | therapeutic_target | gene | 0.60 |
| ARG1 | therapeutic_target | gene | 0.60 |
| NOS3 | therapeutic_target | gene | 0.60 |
| NPY | regulates | gene | 0.60 |
| GAD1 | inhibits | gene | 0.60 |
| BDNF | regulates | gene | 0.60 |
| TRKB | inhibits | gene | 0.60 |
| SST | regulates | gene | 0.60 |
| PVALB | inhibits | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| AND | therapeutic_target | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| DEPRESSION | inhibits | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| GABA | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||