gene

GAD2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GAD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections
0Hypotheses
0Analyses
41Outgoing
24Incoming

Summary

GAD2 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, implicated in. Associated with Als, Cardiac, Diabetes. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolGAD2
Full NameGlutamate Decarboxylase 2
Chromosome10p12.1
Protein TypeReceptor
FunctionIt plays critical roles in ciliary signaling, neuronal migration, and synaptic function.
Primary Expressionregions affected in Parkinson disease
UniProt IDQ96S44
NCBI Gene ID2572
Ensembl IDENSG00000136750
OMIM300036
GeneCardsGAD2
Human Protein AtlasGAD2
Associated DiseasesAls
InteractionsGAD1, PVALB, TRKB, DEPRESSION, Ras
KG Connections65 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: GAD2 — AlphaFold Q96S44 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Glutamate Decarboxylase 2

gene · 917 words

gabaergic-dysfunction

mechanism · 4621 words

Cortical Ivy Cells

cell · 2948 words

Chemogenetically Modified Neurons

cell · 2410 words

Olfactory Bulb Granule Cells

cell · 2408 words

USH1C Gene

gene · 2382 words

Pathway Diagram

graph TD
    GAD2["<b>GAD2</b>"]
    Als{"Als"}
    GAD2 -->|"associated with"| Als
    Cardiac{"Cardiac"}
    GAD2 -->|"regulates"| Cardiac
    Diabetes{"Diabetes"}
    GAD2 -->|"regulates"| Diabetes
    GAD2 -->|"regulates"| Als
    PIK3CB["PIK3CB"]
    GAD2 -->|"regulates"| PIK3CB
    NOS1["NOS1"]
    GAD2 -->|"regulates"| NOS1
    CFTR["CFTR"]
    GAD2 -->|"regulates"| CFTR
    EPHB4["EPHB4"]
    GAD2 -->|"associated with"| EPHB4
    MMP2["MMP2"]
    GAD2 -->|"associated with"| MMP2
    HIP1R["HIP1R"]
    GAD2 -->|"regulates"| HIP1R
    USH1C["USH1C"]
    GAD2 -->|"regulates"| USH1C
    neurodegeneration["neurodegeneration"]
    GAD2 -->|"implicated in"| neurodegeneration
    RYR2["RYR2"]
    RYR2 -->|"regulates"| GAD2
    SCN1A["SCN1A"]
    SCN1A -->|"regulates"| GAD2
    ROBO1["ROBO1"]
    ROBO1 -->|"associated with"| GAD2
    ABCD3["ABCD3"]
    ABCD3 -->|"regulates"| GAD2
    HNF4A["HNF4A"]
    HNF4A -->|"expressed in"| GAD2
    style GAD2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (41)

TargetRelationTypeStr
Alsassociated_withdisease0.65
Cardiacregulatesdisease0.65
Diabetesregulatesdisease0.65
Alsregulatesdisease0.65
Mstherapeutic_targetdisease0.65

Incoming (24)

SourceRelationTypeStr
RYR2regulatesgene0.60
SCN1Aregulatesgene0.60
ROBO1associated_withgene0.60
ABCD3regulatesgene0.60
HNF4Aexpressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found