gene

NOS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

73Connections
0Hypotheses
0Analyses
50Outgoing
20Incoming

Summary

NOS1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with Als, Cardiac, Ms. Connected to 14 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolNOS1
Full NameNitric Oxide Synthase 1
Chromosome12q24.2
Protein TypeEnzyme
FunctionNOS1 produces nitric oxide, which serves multiple functions in the nervous system.
Subcellular LocalizationCytoplasm, Membrane
Molecular Weight160 kDa
PathwaysMAPK signaling, lipid metabolism, oxidative stress response
UniProt IDP70689 (mouse), Q9WU75 (rat)
Ensembl IDENSG00000089250
GeneCardsNOS1
Human Protein AtlasNOS1
Presynaptic plasticityNO regulates the release of various neurotransmitters including glutamate, GABA, dopamine, and acetylcholine
Retrograde signalingNO acts as a messenger for long-term potentiation (LTP) and long-term depression (LTD)
NeuromodulationNO influences neuronal excitability and firing patterns
Associated DiseasesAls, neuroinflammation, oxidative stress
InteractionsIL6, APOE, SERPINA3, CD44, MAPK1, CLU
KG Connections73 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: NOS1 — AlphaFold P70689 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

NOS1 — Nitric Oxide Synthase 1

gene · 2034 words

cGMP Signaling Pathway in Neurodegeneration

mechanism · 3523 words

Supramammillary Neurons

cell · 3160 words

Neuronal Nitric Oxide Synthase Neurons

cell · 2510 words

Gasotransmitters in Neuroprotection - AD/PD

mechanism · 2466 words

Striatal Interneurons in Huntington's Disease

cell · 2034 words

Pathway Diagram

graph TD
    NOS1["<b>NOS1</b>"]
    Ms{"Ms"}
    NOS1 -->|"activates"| Ms
    Als{"Als"}
    NOS1 -->|"associated with"| Als
    Cardiac{"Cardiac"}
    NOS1 -->|"regulates"| Cardiac
    CFTR["CFTR"]
    NOS1 -->|"regulates"| CFTR
    EPHB4["EPHB4"]
    NOS1 -->|"associated with"| EPHB4
    MMP2["MMP2"]
    NOS1 -->|"associated with"| MMP2
    HIP1R["HIP1R"]
    NOS1 -->|"regulates"| HIP1R
    neurodegeneration["neurodegeneration"]
    NOS1 -->|"implicated in"| neurodegeneration
    AMPK["AMPK"]
    AMPK -->|"activates"| NOS1
    RYR2["RYR2"]
    RYR2 -->|"regulates"| NOS1
    SCN1A["SCN1A"]
    SCN1A -->|"regulates"| NOS1
    ROBO1["ROBO1"]
    ROBO1 -->|"associated with"| NOS1
    GAD2["GAD2"]
    GAD2 -->|"regulates"| NOS1
    PIK3CB["PIK3CB"]
    PIK3CB -->|"regulates"| NOS1
    style NOS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (53)

TargetRelationTypeStr
Msactivatesdisease0.65
Alsassociated_withdisease0.65
Cardiacregulatesdisease0.65
Alzheimerinteracts_withdisease0.65
Neuroinflammationinteracts_withdisease0.65

Incoming (20)

SourceRelationTypeStr
RYR2regulatesgene0.60
SCN1Aregulatesgene0.60
ROBO1associated_withgene0.60
GAD2regulatesgene0.60
PIK3CBregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found