Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NOS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NOS1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with Als, Cardiac, Ms. Connected to 14 entities in the SciDEX knowledge graph.
| Gene Symbol | NOS1 |
| Full Name | Nitric Oxide Synthase 1 |
| Chromosome | 12q24.2 |
| Protein Type | Enzyme |
| Function | NOS1 produces nitric oxide, which serves multiple functions in the nervous system. |
| Subcellular Localization | Cytoplasm, Membrane |
| Molecular Weight | 160 kDa |
| Pathways | MAPK signaling, lipid metabolism, oxidative stress response |
| UniProt ID | P70689 (mouse), Q9WU75 (rat) |
| Ensembl ID | ENSG00000089250 |
| GeneCards | NOS1 |
| Human Protein Atlas | NOS1 |
| Presynaptic plasticity | NO regulates the release of various neurotransmitters including glutamate, GABA, dopamine, and acetylcholine |
| Retrograde signaling | NO acts as a messenger for long-term potentiation (LTP) and long-term depression (LTD) |
| Neuromodulation | NO influences neuronal excitability and firing patterns |
| Associated Diseases | Als, neuroinflammation, oxidative stress |
| Interactions | IL6, APOE, SERPINA3, CD44, MAPK1, CLU |
| KG Connections | 73 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NOS1["<b>NOS1</b>"]
Ms{"Ms"}
NOS1 -->|"activates"| Ms
Als{"Als"}
NOS1 -->|"associated with"| Als
Cardiac{"Cardiac"}
NOS1 -->|"regulates"| Cardiac
CFTR["CFTR"]
NOS1 -->|"regulates"| CFTR
EPHB4["EPHB4"]
NOS1 -->|"associated with"| EPHB4
MMP2["MMP2"]
NOS1 -->|"associated with"| MMP2
HIP1R["HIP1R"]
NOS1 -->|"regulates"| HIP1R
neurodegeneration["neurodegeneration"]
NOS1 -->|"implicated in"| neurodegeneration
AMPK["AMPK"]
AMPK -->|"activates"| NOS1
RYR2["RYR2"]
RYR2 -->|"regulates"| NOS1
SCN1A["SCN1A"]
SCN1A -->|"regulates"| NOS1
ROBO1["ROBO1"]
ROBO1 -->|"associated with"| NOS1
GAD2["GAD2"]
GAD2 -->|"regulates"| NOS1
PIK3CB["PIK3CB"]
PIK3CB -->|"regulates"| NOS1
style NOS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | activates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Cardiac | regulates | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Neuroinflammation | interacts_with | disease | 0.65 |
| Inflammation | interacts_with | disease | 0.65 |
| CFTR | regulates | gene | 0.60 |
| EPHB4 | associated_with | gene | 0.60 |
| MMP2 | associated_with | gene | 0.60 |
| HIP1R | regulates | gene | 0.60 |
| IL6 | interacts_with | gene | 0.60 |
| APOE | interacts_with | gene | 0.60 |
| SERPINA3 | interacts_with | gene | 0.60 |
| PRDX6 | associated_with | gene | 0.60 |
| MT1A | associated_with | gene | 0.60 |
| CD44 | interacts_with | gene | 0.60 |
| SOD1 | associated_with | gene | 0.60 |
| MAPK1 | interacts_with | gene | 0.60 |
| CLU | interacts_with | gene | 0.60 |
| TNF | interacts_with | gene | 0.60 |
| NFE2L2 | associated_with | gene | 0.60 |
| MMP1 | interacts_with | gene | 0.60 |
| GFAP | interacts_with | gene | 0.60 |
| CRYAB | interacts_with | gene | 0.60 |
| LRP1 | interacts_with | gene | 0.60 |
| CATHEPSINS | interacts_with | gene | 0.60 |
| TNF | associated_with | gene | 0.60 |
| neuroinflammation | associated_with | disease | 0.60 |
| NEUROINFLAMMATION | interacts_with | gene | 0.60 |
| OXIDATIVE STRESS | interacts_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| ASTROCYTES | interacts_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | interacts_with | gene | 0.60 |
| HSPB1 | interacts_with | gene | 0.60 |
| ASTROCYTE | interacts_with | gene | 0.60 |
| ALZHEIMER | interacts_with | gene | 0.60 |
| Oxidative Stress | interacts_with | pathway | 0.60 |
| Mapk | interacts_with | pathway | 0.60 |
| Sod1 | associated_with | pathway | 0.60 |
| Lipid Metabolism | associated_with | pathway | 0.60 |
| lipid metabolism | participates_in | pathway | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| Astrocyte | expressed_in | cell_type | 0.55 |
| MMP1 | associated_with | gene | 0.50 |
| CRYAB | associated_with | gene | 0.50 |
| SERPINA3 | associated_with | gene | 0.50 |
| HSPB1 | associated_with | gene | 0.50 |
| oxidative stress | associated_with | phenotype | 0.50 |
| LIPID METABOLISM | associated_with | pathway | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RYR2 | regulates | gene | 0.60 |
| SCN1A | regulates | gene | 0.60 |
| ROBO1 | associated_with | gene | 0.60 |
| GAD2 | regulates | gene | 0.60 |
| PIK3CB | regulates | gene | 0.60 |
| CLU | associated_with | gene | 0.60 |
| CRYAB | associated_with | gene | 0.60 |
| IL6 | associated_with | gene | 0.60 |
| MMP1 | associated_with | gene | 0.60 |
| MT1A | associated_with | gene | 0.60 |
| NFE2L2 | associated_with | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| HSPB1 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.50 |
| LRP1 | associated_with | gene | 0.50 |
| GFAP | associated_with | gene | 0.50 |
| CD44 | associated_with | gene | 0.50 |
| PRDX6 | associated_with | gene | 0.50 |
| MAPK1 | associated_with | gene | 0.50 |
| Neuroinflammation | associated_with | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||