EPHB4

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPHB4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

EPHB4 (Eph Receptor B4) is a member of the Eph receptor tyrosine kinase family that plays crucial roles in neural development, synaptic plasticity, cellular communication, and blood-brain barrier function. Dysregulated EPHB4 signaling has been implicated in neurodegenerative diseases including Alzheimer's disease and Parkinson's disease.

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flowchart TD
    h_e6437136["h-e6437136"] -->|"therapeutic target"| EPHB4["EPHB4"]
    h_e6437136["h-e6437136"] -->|"targets"| EPHB4["EPHB4"]
    AGGF1["AGGF1"] -->|"upregulates"| EPHB4["EPHB4"]
    EPHB4["EPHB4"] -->|"associated with"| Cancer["Cancer"]
    EPHB4["EPHB4"] -->|"interacts with"| Carcinoma["Carcinoma"]
    EPHB4["EPHB4"] -->|"interacts with"| Ms["Ms"]
    EPHB4["EPHB4"] -->|"interacts with"| Tumor["Tumor"]
    EPHB4["EPHB4"] -->|"associated with"| Ms["Ms"]
    EPHB4["EPHB4"] -->|"associated with"| Als["Als"]
    EPHB4["EPHB4"] -->|"activates"| Aging["Aging"]
    EPHB4["EPHB4"] -->|"activates"| Ms["Ms"]
    EPHB4["EPHB4"] -->|"activates"| Als["Als"]
    style h_e6437136 fill:#006494,stroke:#333,color:#e0e0e0
    style EPHB4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style AGGF1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Carcinoma fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0