gene

PIK3CB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIK3CB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

73Connections
0Hypotheses
0Analyses
46Outgoing
27Incoming

Summary

PIK3CB is a gene implicated in neurodegeneration research. Key relationships include: expressed in, therapeutic target, associated with. Associated with Als, Cancer, Carcinoma. Connected to 60 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolPIK3CB
Full NamePhosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Beta
Chromosome22q13.33
Functionis a major signaling cascade in neurons
Amino Acids1048 aa
PathwaysPI3K, mTOR signaling
UniProt IDQ14184
NCBI Gene ID5293
Ensembl IDENSG00000077150
GeneCardsPIK3CB
Human Protein AtlasPIK3CB
Alternative NamesPI3Kβ, p110β
Brain RegionExpression Level
Cerebral CortexHigh
HippocampusHigh
Associated DiseasesAls, Ms
KG Connections73 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: PIK3CB — AlphaFold Q14184 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

PIK3CB — Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Beta

gene · 1512 words

pi3k-akt-signaling

mechanism · 2556 words

PI3K/Akt Signaling in Neurodegeneration

mechanism · 1803 words

PIK3R3 Gene

gene · 1740 words

PI3K/Akt Signaling in Parkinson's Disease

mechanism · 1674 words

PI3K — Phosphoinositide 3-Kinase

gene · 1532 words

Pathway Diagram

graph TD
    PIK3CB["<b>PIK3CB</b>"]
    Als{"Als"}
    PIK3CB -->|"associated with"| Als
    Ms{"Ms"}
    PIK3CB -->|"associated with"| Ms
    Carcinoma{"Carcinoma"}
    PIK3CB -->|"therapeutic target"| Carcinoma
    Cancer{"Cancer"}
    PIK3CB -->|"therapeutic target"| Cancer
    Tumor{"Tumor"}
    PIK3CB -->|"therapeutic target"| Tumor
    Cardiac{"Cardiac"}
    PIK3CB -->|"regulates"| Cardiac
    RALB["RALB"]
    PIK3CB -->|"expressed in"| RALB
    AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"]
    PIK3CB -->|"associated with"| AUTOPHAGY_RELATED_GENES
    GNAI3["GNAI3"]
    PIK3CB -->|"expressed in"| GNAI3
    WIPI1["WIPI1"]
    PIK3CB -->|"expressed in"| WIPI1
    Autophagy(["Autophagy"])
    PIK3CB -->|"associated with"| Autophagy
    PIK3R1["PIK3R1"]
    PIK3CB -->|"therapeutic target"| PIK3R1
    MIRNAS["MIRNAS"]
    MIRNAS -->|"associated with"| PIK3CB
    C9ORF72["C9ORF72"]
    C9ORF72 -->|"expressed in"| PIK3CB
    CD8["CD8"]
    CD8 -->|"associated with"| PIK3CB
    LRRK2["LRRK2"]
    LRRK2 -->|"expressed in"| PIK3CB
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"associated with"| PIK3CB
    MICRORNAS["MICRORNAS"]
    MICRORNAS -->|"associated with"| PIK3CB
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"associated with"| PIK3CB
    GBA["GBA"]
    GBA -->|"expressed in"| PIK3CB
    WDFY3["WDFY3"]
    WDFY3 -->|"expressed in"| PIK3CB
    PIK3CA["PIK3CA"]
    PIK3CA -->|"therapeutic target"| PIK3CB
    MTOR["MTOR"]
    MTOR -->|"therapeutic target"| PIK3CB
    PIK3CD["PIK3CD"]
    PIK3CD -->|"therapeutic target"| PIK3CB
    style PIK3CB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (46)

TargetRelationTypeStr
ds-83b31ef18d49provides_data_fordataset1.00
Alsassociated_withdisease0.65
Msassociated_withdisease0.65
Carcinomatherapeutic_targetdisease0.65
Cancertherapeutic_targetdisease0.65

Incoming (27)

SourceRelationTypeStr
ds-83b31ef18d49data_indataset1.00
C9ORF72expressed_ingene0.60
CD8associated_withgene0.60
LRRK2expressed_ingene0.60
GBAexpressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found