Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PIK3CB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PIK3CB is a gene implicated in neurodegeneration research. Key relationships include: expressed in, therapeutic target, associated with. Associated with Als, Cancer, Carcinoma. Connected to 60 entities in the SciDEX knowledge graph.
| Gene Symbol | PIK3CB |
| Full Name | Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Beta |
| Chromosome | 22q13.33 |
| Function | is a major signaling cascade in neurons |
| Amino Acids | 1048 aa |
| Pathways | PI3K, mTOR signaling |
| UniProt ID | Q14184 |
| NCBI Gene ID | 5293 |
| Ensembl ID | ENSG00000077150 |
| GeneCards | PIK3CB |
| Human Protein Atlas | PIK3CB |
| Alternative Names | PI3Kβ, p110β |
| Brain Region | Expression Level |
| Cerebral Cortex | High |
| Hippocampus | High |
| Associated Diseases | Als, Ms |
| KG Connections | 73 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PIK3CB["<b>PIK3CB</b>"]
Als{"Als"}
PIK3CB -->|"associated with"| Als
Ms{"Ms"}
PIK3CB -->|"associated with"| Ms
Carcinoma{"Carcinoma"}
PIK3CB -->|"therapeutic target"| Carcinoma
Cancer{"Cancer"}
PIK3CB -->|"therapeutic target"| Cancer
Tumor{"Tumor"}
PIK3CB -->|"therapeutic target"| Tumor
Cardiac{"Cardiac"}
PIK3CB -->|"regulates"| Cardiac
RALB["RALB"]
PIK3CB -->|"expressed in"| RALB
AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"]
PIK3CB -->|"associated with"| AUTOPHAGY_RELATED_GENES
GNAI3["GNAI3"]
PIK3CB -->|"expressed in"| GNAI3
WIPI1["WIPI1"]
PIK3CB -->|"expressed in"| WIPI1
Autophagy(["Autophagy"])
PIK3CB -->|"associated with"| Autophagy
PIK3R1["PIK3R1"]
PIK3CB -->|"therapeutic target"| PIK3R1
MIRNAS["MIRNAS"]
MIRNAS -->|"associated with"| PIK3CB
C9ORF72["C9ORF72"]
C9ORF72 -->|"expressed in"| PIK3CB
CD8["CD8"]
CD8 -->|"associated with"| PIK3CB
LRRK2["LRRK2"]
LRRK2 -->|"expressed in"| PIK3CB
IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
IMMUNE_INFILTRATION -->|"associated with"| PIK3CB
MICRORNAS["MICRORNAS"]
MICRORNAS -->|"associated with"| PIK3CB
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"associated with"| PIK3CB
GBA["GBA"]
GBA -->|"expressed in"| PIK3CB
WDFY3["WDFY3"]
WDFY3 -->|"expressed in"| PIK3CB
PIK3CA["PIK3CA"]
PIK3CA -->|"therapeutic target"| PIK3CB
MTOR["MTOR"]
MTOR -->|"therapeutic target"| PIK3CB
PIK3CD["PIK3CD"]
PIK3CD -->|"therapeutic target"| PIK3CB
style PIK3CB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Cardiac | regulates | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Gastric Cancer | expressed_in | disease | 0.65 |
| RALB | expressed_in | gene | 0.60 |
| GNAI3 | expressed_in | gene | 0.60 |
| WIPI1 | expressed_in | gene | 0.60 |
| PIK3R1 | therapeutic_target | gene | 0.60 |
| NOS1 | regulates | gene | 0.60 |
| CFTR | regulates | gene | 0.60 |
| EPHB4 | associated_with | gene | 0.60 |
| MMP2 | associated_with | gene | 0.60 |
| HIP1R | regulates | gene | 0.60 |
| TSC1 | expressed_in | gene | 0.60 |
| AKT | expressed_in | gene | 0.60 |
| MTOR | expressed_in | gene | 0.60 |
| PI3K | therapeutic_target | gene | 0.60 |
| AKT3 | therapeutic_target | gene | 0.60 |
| PIK3CA | therapeutic_target | gene | 0.60 |
| PIK3CD | therapeutic_target | gene | 0.60 |
| AKT | therapeutic_target | gene | 0.60 |
| MTOR | therapeutic_target | gene | 0.60 |
| AUTOPHAGY-RELATED GENES | associated_with | gene | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Akt | therapeutic_target | pathway | 0.60 |
| Mtor | therapeutic_target | pathway | 0.60 |
| Pi3K | therapeutic_target | pathway | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| MICRORNAS | expressed_in | gene | 0.60 |
| Pi3K/Akt | expressed_in | pathway | 0.60 |
| Mtor | expressed_in | pathway | 0.60 |
| Invasion | expressed_in | pathway | 0.60 |
| Microrna | expressed_in | pathway | 0.60 |
| Angiogenesis | expressed_in | pathway | 0.60 |
| AND | therapeutic_target | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| MIRNAS | therapeutic_target | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| benchmark_ot_ad_answer_key:PIK3CB | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| C9ORF72 | expressed_in | gene | 0.60 |
| CD8 | associated_with | gene | 0.60 |
| LRRK2 | expressed_in | gene | 0.60 |
| GBA | expressed_in | gene | 0.60 |
| WDFY3 | expressed_in | gene | 0.60 |
| PIK3CA | therapeutic_target | gene | 0.60 |
| MTOR | therapeutic_target | gene | 0.60 |
| PIK3CD | therapeutic_target | gene | 0.60 |
| PI3K | therapeutic_target | gene | 0.60 |
| AKT | therapeutic_target | gene | 0.60 |
| PIK3R3 | therapeutic_target | gene | 0.60 |
| AKT3 | therapeutic_target | gene | 0.60 |
| RYR2 | regulates | gene | 0.60 |
| SCN1A | regulates | gene | 0.60 |
| ROBO1 | associated_with | gene | 0.60 |
| GAD2 | regulates | gene | 0.60 |
| PI3K | expressed_in | gene | 0.60 |
| MIRNAS | associated_with | gene | 0.60 |
| IMMUNE INFILTRATION | associated_with | gene | 0.60 |
| MICRORNAS | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| MIRNAS | therapeutic_target | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| MICRORNAS | therapeutic_target | gene | 0.60 |
| MIRNAS | expressed_in | gene | 0.60 |
| benchmark_ot_ad_answer_key:PIK3CB | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||