gene

SERPINA3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SERPINA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

172Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

SERPINA3 Gene — Alpha-1 Antichymotrypsin in Neurodegeneration

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🧬 Gene Info

Gene Symbol	SERPINA3
Full Name	Serpin Family A Member 3
Aliases	Alpha-1 Antichymotrypsin in Neurodegeneration
Chromosome	14q32.13
Protein Type	Protease
Function	Limits protease-mediated tissue damage during inflammation
Primary Expression	Brain (astrocytes), liver, lung, immune cells
Molecular Weight	47 kDa
Amino Acids	418 aa
Pathways	MAPK signaling, lipid metabolism, oxidative stress response
UniProt ID	[P01011](https://www.uniprot.org/uniprot/P01011)
GeneCards	SERPINA3
Human Protein Atlas	SERPINA3
N-terminal signal peptide	Secretory pathway targeting
Serpin domain	The characteristic serpin fold with reactive center loop (RCL)
Associated Diseases	Alzheimer, Alzheimer's Disease, Dementia, Inflammation, Neurodegeneration, Neuroinflammation
Interactions	APOE, LRP1, IL6, GFAP, NFE2L2, TREM2
KG Connections	172 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SERPINA3["<b>SERPINA3</b>"]
    Alzheimer{"Alzheimer"}
    SERPINA3 -->|"therapeutic target"| Alzheimer
    Als{"Als"}
    SERPINA3 -->|"therapeutic target"| Als
    Inflammation{"Inflammation"}
    SERPINA3 -->|"therapeutic target"| Inflammation
    Ms{"Ms"}
    SERPINA3 -->|"therapeutic target"| Ms
    SERPINA3 -->|"expressed in"| Ms
    Neuroinflammation{"Neuroinflammation"}
    SERPINA3 -->|"expressed in"| Neuroinflammation
    SERPINA3 -->|"expressed in"| Inflammation
    PCK1["PCK1"]
    SERPINA3 -->|"therapeutic target"| PCK1
    CD163["CD163"]
    SERPINA3 -->|"expressed in"| CD163
    Blood_Brain_Barrier(["Blood-Brain Barrier"])
    SERPINA3 -->|"therapeutic target"| Blood_Brain_Barrier
    S100A9["S100A9"]
    SERPINA3 -->|"expressed in"| S100A9
    neurodegeneration["neurodegeneration"]
    SERPINA3 -->|"implicated in"| neurodegeneration
    HNRNPD["HNRNPD"]
    HNRNPD -->|"stabilizes"| SERPINA3
    ICAM1["ICAM1"]
    ICAM1 -->|"therapeutic target"| SERPINA3
    CXCL1["CXCL1"]
    CXCL1 -->|"therapeutic target"| SERPINA3
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"therapeutic target"| SERPINA3
    SOCS3["SOCS3"]
    SOCS3 -->|"therapeutic target"| SERPINA3
    IL6["IL6"]
    IL6 -->|"therapeutic target"| SERPINA3
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"therapeutic target"| SERPINA3
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"therapeutic target"| SERPINA3
    C5AR1["C5AR1"]
    C5AR1 -->|"expressed in"| SERPINA3
    TNF["TNF"]
    TNF -->|"therapeutic target"| SERPINA3
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"therapeutic target"| SERPINA3
    ZFP36["ZFP36"]
    ZFP36 -->|"expressed in"| SERPINA3
    style SERPINA3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (100)

Target	Relation	Type	Str
Alzheimer's Disease	causes	disease	0.75
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Neuroinflammation	interacts_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Inflammation	interacts_with	disease	0.65
CD163	expressed_in	gene	0.60
S100A9	expressed_in	gene	0.60
IL6	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
ICAM1	therapeutic_target	gene	0.60
SOCS3	therapeutic_target	gene	0.60
CXCL1	therapeutic_target	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
APOE	interacts_with	gene	0.60
LRP1	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
CD44	associated_with	gene	0.60
GFAP	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
APOE	activates	gene	0.60
TREM2	activates	gene	0.60
APOE4	activates	gene	0.60
NRXN2	inhibits	gene	0.60
VGF	inhibits	gene	0.60
CTSB	inhibits	gene	0.60
CTSD	inhibits	gene	0.60
PRDX6	interacts_with	gene	0.60
MT1A	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
MMP1	associated_with	gene	0.60
CRYAB	interacts_with	gene	0.60
CATHEPSINS	interacts_with	gene	0.60
TYROBP	activates	gene	0.60
SOD1	associated_with	gene	0.60

Incoming (72)

Source	Relation	Type	Str
HNRNPD	stabilizes	protein	0.80
ICAM1	therapeutic_target	gene	0.60
CXCL1	therapeutic_target	gene	0.60
SOCS3	therapeutic_target	gene	0.60
IL6	therapeutic_target	gene	0.60
C5AR1	expressed_in	gene	0.60
TNF	therapeutic_target	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
IL1RN	expressed_in	gene	0.60
MMP3	expressed_in	gene	0.60
IL1R1	activates	gene	0.60
CRYAB	interacts_with	gene	0.60
PRDX6	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
TYROBP	activates	gene	0.60
CST3	inhibits	gene	0.60
CTSS	inhibits	gene	0.60
NPTX1	inhibits	gene	0.60
NOS1	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
APOE	activates	gene	0.60
APOE4	activates	gene	0.60
CATHEPSINS	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
LRP1	interacts_with	gene	0.60
CLU	associated_with	gene	0.60
IL6	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
ZFP36	expressed_in	gene	0.60
IL-6	therapeutic_target	gene	0.60
HSPB1	therapeutic_target	gene	0.60
MICROGLIA	expressed_in	gene	0.60
MIRNAS	expressed_in	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
NEUROINFLAMMATION	expressed_in	gene	0.60
PCK1	therapeutic_target	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ASTROCYTE	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Granzyme B Inhibition with Serpina3n to Preserve Axonal Inte	0.514	neuroimmunology	Do CXCL10-recruited CD8+ T cells provide

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SERPINA3

Understanding Entity Pages

Summary

Wiki Pages (9)

SERPINA3 Gene — Alpha-1 Antichymotrypsin in Neurodegeneration

Serpin Neuroprotection in Neurodegeneration

A2M Protein

Interleukin-1 Receptor Type 1 Protein

HNRNPD Gene

Cathepsin S Protein

IL1R1 Gene