Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HPA AXIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | HPA AXIS |
Knowledge base pages for this entity
graph TD
HPA_AXIS["HPA AXIS"]
HPA_AXIS -->|"involved_in"| Hypersexual_Disorder["Hypersexual Disorder"]
HPA_AXIS -->|"component_of"| Gut_Brain_Axis["Gut-Brain Axis"]
HPA_AXIS -->|"dysregulation_associated_with"| depression["depression"]
HPA_AXIS -->|"modulates"| Sepsis_Associated_Encephalopat["Sepsis-Associated Encephalopathy"]
HPA_AXIS -->|"implicated in"| Alzheimer_s_disease["Alzheimer's disease"]
HPA_AXIS -->|"implicated in"| DEPRESSION["DEPRESSION"]
Chronic_Stress["Chronic Stress"] -->|"activates"| HPA_AXIS
METHYLATION["METHYLATION"] -->|"regulates"| HPA_AXIS
CRH["CRH"] -->|"involved_in"| HPA_AXIS
CRHBP["CRHBP"] -->|"involved_in"| HPA_AXIS
CRHR1["CRHR1"] -->|"involved_in"| HPA_AXIS
FKBP5["FKBP5"] -->|"involved_in"| HPA_AXIS
gut_microbiota["gut microbiota"] -->|"modulates"| HPA_AXIS
Ginsenoside_Rg1["Ginsenoside Rg1"] -->|"inhibits"| HPA_AXIS| Target | Relation | Type | Str |
|---|---|---|---|
| Hypersexual Disorder | associated_with | disease | 0.95 |
| Hypersexual Disorder | involved_in | disease | 0.90 |
| Gut-Brain Axis | component_of | pathway | 0.85 |
| depression | dysregulation_associated_with | disease | 0.85 |
| Sepsis-Associated Encephalopathy | modulates | disease | 0.85 |
| Hypersexual Disorder | involved_in | disease | 0.85 |
| Depression | associated_with | disease | 0.80 |
| Alzheimer's disease | implicated_in | disease | 0.80 |
| DEPRESSION | implicated_in | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Chronic Stress | activates | process | 0.95 |
| CRHR2 | involved_in | gene | 0.95 |
| NR3C1 | involved_in | gene | 0.95 |
| METHYLATION | regulates | process | 0.90 |
| CRH | involved_in | gene | 0.90 |
| CRHR1 | involved_in | gene | 0.90 |
| FKBP5 | involved_in | gene | 0.90 |
| CRHBP | involved_in | gene | 0.90 |
| gut microbiota | modulates | process | 0.85 |
| Ginsenoside Rg1 | inhibits | compound | 0.85 |
| DNA methylation | regulates | process | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||