Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CRHBP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CRHBP |
| Key Genes/Proteins | FKBP5, CRH, DNA, JUN, TNF-ALPHA, NR3C1 |
| Related Diseases | Hypersexual Disorder, Depression, Addiction |
| Related Pathways | Hpa Axis, DNA Methylation, Epigenetic |
Knowledge base pages for this entity
graph TD
CRHBP["CRHBP"]
CRHBP -->|"methylates"| Depression["Depression"]
CRHBP -->|"methylates"| Addiction["Addiction"]
CRHBP -->|"interacts"| FKBP5["FKBP5"]
CRHBP -->|"interacts"| CRH["CRH"]
CRHBP -->|"interacts"| NR3C1["NR3C1"]
CRHBP -->|"interacts"| CRHR1["CRHR1"]
CRHBP -->|"interacts"| AND["AND"]
CRHBP -->|"interacts"| GENES["GENES"]
DNA_Methylation["DNA Methylation"] -->|"regulates"| CRHBP
GENES -->|"interacts"| CRHBP
CRHR1 -->|"interacts"| CRHBP
CRH -->|"interacts"| CRHBP
NR3C1 -->|"interacts"| CRHBP
AND -->|"interacts"| CRHBP
TNF_ALPHA["TNF-ALPHA"] -->|"methylates"| CRHBP
JUN["JUN"] -->|"methylates"| CRHBP| Target | Relation | Type | Str |
|---|---|---|---|
| Hpa Axis | involved_in | pathway | 0.90 |
| Hypersexual Disorder | associated_with | disease | 0.80 |
| Depression | associated_with | disease | 0.65 |
| Depression | methylates | disease | 0.65 |
| Addiction | methylates | disease | 0.65 |
| Addiction | associated_with | disease | 0.65 |
| FKBP5 | interacts_with | gene | 0.60 |
| Epigenetic | associated_with | pathway | 0.60 |
| CRH | interacts_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| JUN | associated_with | gene | 0.60 |
| TNF-ALPHA | associated_with | gene | 0.60 |
| NR3C1 | interacts_with | gene | 0.60 |
| IL-6 | associated_with | gene | 0.60 |
| CRHR1 | interacts_with | gene | 0.60 |
| TNF | associated_with | gene | 0.60 |
| HPA AXIS RELATED GENES | associated_with | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| IL-6 | methylates | gene | 0.60 |
| Epigenetic | methylates | pathway | 0.60 |
| App | associated_with | protein | 0.60 |
| CRHR2 | interacts_with | gene | 0.60 |
| Parkinson's disease | associated_with | disease | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DNA Methylation | regulates | mechanism | 0.85 |
| GENES | interacts_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| TNF | associated_with | gene | 0.60 |
| CRHR1 | interacts_with | gene | 0.60 |
| DEPRESSION | associated_with | gene | 0.60 |
| TNF-ALPHA | associated_with | gene | 0.60 |
| CRH | interacts_with | gene | 0.60 |
| IL-6 | associated_with | gene | 0.60 |
| JUN | associated_with | gene | 0.60 |
| NR3C1 | interacts_with | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| HPA AXIS RELATED GENES | associated_with | gene | 0.60 |
| TNF-ALPHA | methylates | gene | 0.60 |
| JUN | methylates | gene | 0.60 |
| DNA | methylates | gene | 0.60 |
| DEPRESSION | methylates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||