Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GUT MICROBIOTA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | GUT MICROBIOTA |
Knowledge base pages for this entity
graph TD
GUT_MICROBIOTA["GUT MICROBIOTA"]
GUT_MICROBIOTA -->|"modulates"| Central_Nervous_System["Central Nervous System"]
GUT_MICROBIOTA -->|"regulates"| Gut_Brain_Axis["Gut-Brain Axis"]
GUT_MICROBIOTA -->|"regulates"| Central_Nervous_System_Physiol["Central Nervous System Physiology"]
GUT_MICROBIOTA -->|"causes"| Motor_Deficits["Motor Deficits"]
GUT_MICROBIOTA -->|"causes"| Neuroinflammation["Neuroinflammation"]
GUT_MICROBIOTA -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
GUT_MICROBIOTA -->|"causes"| Microglia_Activation["Microglia Activation"]
GUT_MICROBIOTA -->|"product_of"| Tryptophan_Metabolites["Tryptophan Metabolites"]
GUT_MICROBIOTA -->|"modulates"| Mood["Mood"]
Antioxidants["Antioxidants"] -->|"modulates"| GUT_MICROBIOTA
Neural_Pathway["Neural Pathway"] -->|"mediates"| GUT_MICROBIOTA
Fecal_Microbial_Transplantatio["Fecal Microbial Transplantation"] -->|"targets"| GUT_MICROBIOTA
BMAL1["BMAL1"] -->|"regulates"| GUT_MICROBIOTA| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson's Disease | associated_with | disease | 0.95 |
| Indoleacetic Acid | associated_with | compound | 0.95 |
| Central Nervous System | modulates | cell_type | 0.95 |
| Gut-Brain Axis | regulates | pathway | 0.95 |
| Central Nervous System Physiology | regulates | process | 0.95 |
| Motor Deficits | causes | phenotype | 0.95 |
| Neuroinflammation | causes | process | 0.95 |
| Gut-Brain Axis | component_of | pathway | 0.95 |
| Brain Functions | associated_with | process | 0.95 |
| Alzheimer's Disease | involved_in | disease | 0.95 |
| Host Immunity | regulates | process | 0.95 |
| Host Metabolism | regulates | process | 0.95 |
| DNA Methylation | modulates | mechanism | 0.95 |
| Histone Modifications | modulates | mechanism | 0.95 |
| Gut-Microbiome-Brain Axis | mediates | pathway | 0.95 |
| RNA Methylation | modulates | mechanism | 0.95 |
| Parkinson'S Disease | associated_with | disease | 0.95 |
| Alzheimer'S Disease | associated_with | disease | 0.95 |
| Enteric Nervous System | interacts_with | cell_type | 0.95 |
| Parkinson'S Disease | regulates | disease | 0.95 |
| Parkinson's Disease | contributes_to | disease | 0.95 |
| gut-brain axis | regulates | pathway | 0.92 |
| mood | regulates | phenotype | 0.90 |
| neuroinflammation | promotes | process | 0.90 |
| Tryptophan Metabolites | associated_with | compound | 0.90 |
| Microglia Activation | causes | process | 0.90 |
| Tryptophan Metabolites | product_of | compound | 0.90 |
| Mood | modulates | phenotype | 0.90 |
| Cognition | modulates | phenotype | 0.90 |
| Brain | modulates | cell_type | 0.90 |
| Glycerophospholipid Metabolism | regulates | pathway | 0.90 |
| Indole Derivatives | product_of | compound | 0.90 |
| Obesity | associated_with | disease | 0.90 |
| N6-Methyladenosine | regulates | compound | 0.90 |
| Central Nervous System | associated_with | cell_type | 0.90 |
| Disease Pathogenesis | contributes_to | mechanism | 0.90 |
| Glaucoma | protects_against | disease | 0.90 |
| microglia activation | regulates | process | 0.88 |
| Immune System | modulates | process | 0.88 |
| Metabolite Production | regulates | process | 0.88 |
| Neuroinflammation | modulates | process | 0.88 |
| Tau-Mediated Neurodegeneration | contributes_to | process | 0.88 |
| Central Nervous System Homeostasis | regulates | process | 0.87 |
| depression | associated_with | disease | 0.85 |
| HPA axis | modulates | pathway | 0.85 |
| SNCA Pathology | modulates | process | 0.85 |
| Parkinson's Disease | risk_factor_for | disease | 0.85 |
| Microglia Activation | modulates | process | 0.85 |
| Neuroinflammation | regulates | process | 0.85 |
| Central Nervous System | interacts_with | structure | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Antioxidants | modulates | compound | 0.95 |
| IPA | associated_with | compound | 0.95 |
| TCM polyphenols | regulates | drug | 0.90 |
| Neural Pathway | mediates | pathway | 0.90 |
| AGING | modulates | phenotype | 0.90 |
| APOE | interacts_with | gene | 0.88 |
| vagus nerve | interacts_with | pathway | 0.85 |
| antidepressants | interacts_with | drug | 0.85 |
| fecal microbiota transplantation | modulates | drug | 0.85 |
| Fecal Microbial Transplantation | targets | drug | 0.85 |
| Quinic Acid | modulates | compound | 0.85 |
| Postbiotics | modulates | compound | 0.85 |
| Fecal Microbial Transplantation | modulates | drug | 0.80 |
| Akkermansia Muciniphila | modulates | compound | 0.80 |
| Traditional Chinese Medicine | modulates | drug | 0.75 |
| BMAL1 | regulates | gene | 0.70 |
| Parkinson's disease | associated_with | disease | 0.70 |
| Neuroinflammation | regulates | process | 0.50 |
| PARKINSON | regulates | gene | 0.50 |
| Parkinson's Disease | regulates | disease | 0.50 |
| disease | regulates | disease | 0.50 |
| PARKINSON'S | regulates | concept | 0.50 |
| Microbiota | regulates | process | 0.50 |
| microglia | activates | cell_type | 0.50 |
| Microbiota | activates | process | 0.50 |
| Microbiota | associated_with | process | 0.50 |
| AUTISM | associated_with | disease | 0.50 |
| SCHIZOPHRENIA | associated_with | disease | 0.50 |
| ALZHEIMER | associated_with | gene | 0.50 |
| PARKINSON | associated_with | gene | 0.50 |
| Alzheimer'S Disease | associated_with | disease | 0.50 |
| OBESITY | associated_with | disease | 0.50 |
| ANXIETY | associated_with | gene | 0.50 |
| disease | associated_with | disease | 0.50 |
| ALZHEIMER'S | associated_with | concept | 0.50 |
| PARKINSON'S | associated_with | concept | 0.50 |
| Neurodegeneration | interacts_with | disease | 0.50 |
| Microbiota | interacts_with | process | 0.50 |
| Dysbiosis | interacts_with | disease | 0.50 |
| PARKINSON | interacts_with | gene | 0.50 |
| Parkinson's Disease | interacts_with | disease | 0.50 |
| disease | interacts_with | disease | 0.50 |
| PARKINSON'S | interacts_with | concept | 0.50 |
| inflammation | associated_with | pathway | 0.50 |
| Dysbiosis | associated_with | disease | 0.50 |
| DEPRESSION | inhibits | disease | 0.50 |
| inflammation | inhibits | pathway | 0.50 |
| ANXIETY | inhibits | gene | 0.50 |
| Microbiota | inhibits | process | 0.50 |
| Cognitive Impairment | inhibits | phenotype | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||