Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation.
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| Gene Symbol | IL |
| Full Name | 18 - Interleukin-18 |
| Chromosome | 11q22.2. |
| Function | Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation. |
| GeneCards | IL |
| Human Protein Atlas | IL |
| Pro-inflammatory cytokines | TNF-α, IL-1β |
| Oxidative stress | ROS, mitochondrial dysfunction |
| Elevated levels | IL-18 is significantly elevated in CSF and plasma of AD patients compared to healthy controls |
| Disease correlation | Levels correlate with cognitive decline measured by MMSE and CDR |
| Pathology association | Associated with amyloid-β plaque deposition and tau hyperphosphorylation |
| Conversion prediction | Elevated IL-18 predicts conversion from mild cognitive impairment (MCI) to AD |
| Mechanistic role | Drives neuroinflammation and synaptic dysfunction |
| Therapeutic target | IL-18 neutralization reduces pathology in AD mouse models |
| Associated Diseases | CRC |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
N1["🔬 IL"]
N2["CRC"]
N1 -->|"associated with"| N2
style N1 fill:#1a237e,stroke:#7c4dff,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| CRC | associated_with | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.577
neurodegeneration | 2026-04-16 | 14 hypotheses Top: 0.806
neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.831
clinical neurology | 2026-04-08 | 7 hypotheses Top: 0.455
neurodegeneration | 2026-04-04 | 1 hypotheses Top: 0.380
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Plant-based dietary patterns and Alzheimer's disease risk in multiethn | clinical | Alzheimer's disease and relate | 0.950 | 0.00 | human patients | proposed | N/A |
| SIRPα modulation in mouse models of Alzheimer's disease | validation | Alzheimer's disease | 0.900 | 0.00 | mouse models of Alzheimer's di | proposed | N/A |
| Autophagy receptor identification for stress granule elimination | exploratory | neurodegenerative diseases | 0.900 | 0.00 | cultured cells under arsenite | proposed | N/A |
| NAD depletion effects on monocyte/macrophage differentiation | exploratory | Inflammatory bowel disease | 0.900 | 0.00 | Primary mouse and human monocy | proposed | N/A |
| FK866 treatment in DSS-induced colitis mouse model | validation | Inflammatory bowel disease (co | 0.900 | 0.00 | DSS-induced colitis mice | proposed | N/A |
| Synaptic plasticity and protein expression analysis in mPFC | exploratory | insomnia-anxiety comorbidity | 0.850 | 0.00 | mPFC brain slices from PCPA-tr | proposed | N/A |
| FK866 in azoxymethane/DSS colitis-associated cancer model | validation | Colitis-associated cancer | 0.850 | 0.00 | AOM/DSS-treated mice | proposed | N/A |
| FK866 mechanism validation in Rag1-/- mice | validation | Inflammatory bowel disease | 0.850 | 0.00 | Rag1-/- mice with DSS-induced | proposed | N/A |
| Microglial SIRPα expression in human Alzheimer's disease tissue | exploratory | Alzheimer's disease | 0.800 | 0.00 | human brain tissue | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Roles of NAD+ in Health and Aging. [PMID:37848251] | Lautrup S, Hou Y, Fang EF, Bohr VA | Cold Spring Harbor perspective | 2024 | 0 |
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] | Balusu S, De Strooper B | Acta neuropathologica | 2024 | 0 |
| The different autophagy degradation pathways and neurodegeneration. [PMID:35134347] | Fleming A, Bourdenx M, Fujimaki M, Karab | Neuron | 2022 | 0 |
| Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] | Burillo J, Marqués P, Jiménez B, Gonzále | Cells | 2021 | 0 |
| WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559] | ["Wan Huida", "Wang Qi", "Chen Xiuting", | Autophagy | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559] | ["Wan Huida", "Wang Qi", "Chen Xiuting", | Autophagy | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive defi [PMID:30742114] | Unknown | Nature neuroscience | 2019 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
| Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169] | ["Oakley, Holly", "Cole, Sarah L", "Loga | The Journal of neuroscience : | 2006 | 0 |
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773] | ["Hardy, John", "Selkoe, Dennis J"] | Science (New York, N.Y.) | 2002 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.76 · 2026-04-23
closed · Rounds: 4 · Score: 0.76 · 2026-04-16
closed · Rounds: 7 · Score: 0.87 · 2026-04-16
closed · Rounds: 4 · Score: 0.79 · 2026-04-13
closed · Rounds: 4 · Score: 0.76 · 2026-04-12
closed · Rounds: 4 · Score: 0.78 · 2026-04-12
closed · Rounds: 4 · Score: 0.50 · 2026-04-11
closed · Rounds: 4 · Score: 0.79 · 2026-04-09
closed · Rounds: 4 · Score: 0.90 · 2026-04-06
Hypotheses and analyses mentioning IL in their description or question text
Score: 0.865 · molecular-neurobiology · 2026-04-17
## Mechanistic Overview Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV Interneuron-Spe
Score: 0.862 · neurodegeneration · 2026-04-16
## Mechanistic Overview TREM2 R47H Variant-Driven Metabolic Dysfunction as the Primary Trigger for Failed DAM Transition
Score: 0.840 · protein-biochemistry · 2026-04-28
The HSP90 chaperone system, comprising HSP90AA1 and HSP90AB1 in complex with their cochaperones STIP1 (Stress-Induced Ph
Score: 0.838 · neurodegeneration · 2026-04-17
## Mechanistic Overview Gamma Oscillation Enhancement Synergy starts from the claim that modulating not yet specified wi
Score: 0.833 · synaptic-biology · 2026-04-28
This hypothesis proposes that the CREB-BDNF-TrkB activity-dependent signaling cascade directly controls the spatial posi
Score: 0.831 · neuroinflammation · 2026-04-13
## Mechanistic Overview IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microglia Interface starts from the claim t
Score: 0.829 · translational-neuroscience · 2026-04-16
## Mechanistic Overview Ketone Utilization Index as Metabolic Flexibility Biomarker starts from the claim that modulatin
Score: 0.828 · multi · 2026-04-28
Shared mechanism across ALS, FTD, AD/LATE: Nuclear TDP-43 loss impairs RNA splicing and axonal maintenance; the same mis
Score: 0.827 · alzheimers · 2026-04-16
## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via glymph
Score: 0.820 · neurodegeneration · 2026-04-28
Impaired autophagic flux and lysosomal degradation capacity represents a convergent failure point across AD, PD, ALS, an
Score: 0.811 · neurodegeneration · 2026-04-16
## Mechanistic Overview CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-Specific Vulnerability Thresholds sta
Score: 0.806 · unknown disease · 2026-04-16
## Mechanistic Overview Neutrophil Extracellular Trap (NET) Inhibition starts from the claim that modulating PADI4 withi
Score: 0.796 · multi · 2026-04-28
Shared mechanism across PD, AD, ALS: Mitochondrial damage normally recruits PINK1/Parkin quality control; failure of thi