gene 2,501 words KG: IL13 2026-03-28
kind:genesection:genesstate:published
Contents

IL13 — Interleukin 13

🧬 Gene Info
Gene SymbolIL13
Full NameInterleukin-13
Chromosome5q31.1.
Functionis a Th2-associated cytokine encoded by the IL13 gene on chromosome 5q31.
Amino Acids146 aa
Exons5
PathwaysPI3K, MAPK, NF-κB
UniProt ID[P08960](https://www.uniprot.org/uniprot/P08960)
Ensembl IDENSG00000169194
OMIM147683
GeneCardsIL13
Human Protein AtlasIL13
IL-13v1Full-length isoform (146 aa)
IL-13v2Truncated form with altered C-terminus
IL-13ΔE4Exon 4 deletion variant
Associated DiseasesAtopic Dermatitis, Mitochondrial Dysfunction
Known Drugs/CompoundsTralokinumab
InteractionsCHRNE, WNT11, GRIN3B, TNFRSF1B, TNFRSF13C, HCRTR1
KG Connections94 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.49

Related Analyses (4)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (11)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40
Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti
clinical · proposed · Score: 0.40
ApoE4 Function in Alzheimer's Disease
validation · proposed · Score: 0.40

See Also (15)

Packard Center for ALS Research
institution · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
ICAM1 - Intercellular Adhesion Molecule 1
gene · KG edge: associated_with
HIF1A Gene - Hypoxia Inducible Factor 1 Subunit Alpha
gene · KG edge: associated_with
HCRTR1
gene · KG edge: activates

Knowledge Graph (12 edges)

IL13 activates CHRNE
IL13 activates WNT11
IL13 activates GRIN3B
IL13 activates TNFRSF1B
IL13 activates TNFRSF13C
IL13 activates HCRTR1
IL13 associated_with APOE
IL13 associated_with FGF2
IL13 associated_with CASP1
IL13 associated_with MRC1