gene

IL31

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL31: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections

0Hypotheses

0Analyses

19Outgoing

16Incoming

Summary

IL31 encodes a cytokine of the IL-6 family with roles in inflammation, itch sensation, and neuroimmune interactions relevant to neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	IL31
Full Name	Interleukin 31
Chromosome	9p11.2
Protein Family	IL-6 cytokine family
Molecular Weight	~19 kDa
Amino Acids	164 aa
Exons	5
UniProt ID	Q9Y4K5
NCBI Gene ID	386653
Ensembl ID	ENSG00000099769
OMIM	609271
GeneCards	IL31
Human Protein Atlas	IL31
Encoded Protein	Interleukin-31 (IL-31)
Protein Length	164 amino acids
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	IFNG, S100A9, S100A8, IL22
KG Connections	35 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IL31 — AlphaFold Q9Y4K5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IL31["IL31"]
    Als["Als"]
    Atherosclerosis["Atherosclerosis"]
    Inflammation["Inflammation"]
    S100A9["S100A9"]
    Differentiation["Differentiation"]
    IL4R["IL4R"]
    IL_13["IL-13"]
    CLDN1["CLDN1"]
    S100A8["S100A8"]
    IFNG["IFNG"]
    INFLAMMATION["INFLAMMATION"]
    IL22["IL22"]
    GENES["GENES"]
    RNA["RNA"]
    neurodegeneration["neurodegeneration"]
    IL31 -->|"expressed in"| Als
    IL31 -->|"expressed in"| Atherosclerosis
    IL31 -->|"expressed in"| Inflammation
    IL31 -->|"expressed in"| S100A9
    IL31 -->|"expressed in"| Differentiation
    IL31 -->|"expressed in"| IL4R
    IL31 -->|"expressed in"| IL_13
    IL31 -->|"expressed in"| CLDN1
    IL31 -->|"expressed in"| S100A8
    IFNG -->|"expressed in"| IL31
    S100A8 -->|"expressed in"| IL31
    CLDN1 -->|"expressed in"| IL31
    INFLAMMATION -->|"expressed in"| IL31
    IL22 -->|"expressed in"| IL31
    GENES -->|"expressed in"| IL31
    RNA -->|"expressed in"| IL31
    S100A9 -->|"expressed in"| IL31
    IL31 -->|"implicated_in"| neurodegeneration
    style IL31 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (19)

Target	Relation	Type	Str
Als	expressed_in	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
S100A9	expressed_in	gene	0.60
CLDN1	expressed_in	gene	0.60
S100A8	expressed_in	gene	0.60
IFNG	expressed_in	gene	0.60
LOR	expressed_in	gene	0.60
Differentiation	expressed_in	pathway	0.60
IL4R	expressed_in	gene	0.60
IL-13	expressed_in	gene	0.60
Interleukin	expressed_in	protein	0.60
RNA	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
Il-1	expressed_in	protein	0.60
IFNG	activates	gene	0.50
CLDN1	activates	concept	0.50

Incoming (16)

Source	Relation	Type	Str
Tralokinumab	downregulates	drug	0.90
IFNG	expressed_in	gene	0.60
S100A8	expressed_in	gene	0.60
CLDN1	expressed_in	gene	0.60
IL22	expressed_in	gene	0.60
S100A9	expressed_in	gene	0.60
CCL26	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
IL4R	expressed_in	gene	0.60
IL-13	expressed_in	gene	0.60
S100A9	activates	gene	0.50
S100A8	activates	gene	0.50
IL22	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found