Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IPA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| STAT3 | inhibits | protein | 0.95 |
| WNT1 | inhibits | gene | 0.95 |
| HMOX1 | upregulates | gene | 0.95 |
| NQO1 | upregulates | gene | 0.95 |
| TNF | downregulates | gene | 0.95 |
| IL6 | downregulates | gene | 0.95 |
| Oxidative Stress | suppresses | process | 0.95 |
| Microglia | modulates | cell_type | 0.95 |
| Gut Microbiota | associated_with | cell_type | 0.95 |
| Radiation-Induced Delayed Brain Injury | protects_against | disease | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| H2: Indole-3-Propionate (IPA) as the Actual Neuroprotective | 0.675 | neurodegeneration | How does engineered C. butyricum cross t |
| CLU-APOE-TREM2 Tripartite Axis as a Coordinate Therapeutic T | 0.548 | neurodegeneration | Does clusterin exacerbate or protect aga |
| Cross-Cell Type Synaptic Rescue via Tripartite Synapse Resto | 0.454 | neurodegeneration | Cell type vulnerability in Alzheimer's D |
Scientific analyses that reference this entity
drug delivery | 2026-04-15 | 0 hypotheses
neurodegeneration | 2026-04-15 | 0 hypotheses
research methodology | 2026-04-11 | 0 hypotheses
systems biology | 2026-04-11 | 0 hypotheses
cellular senescence | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||