HMOX1

Understanding Entity Pages

This page aggregates everything SciDEX knows about HMOX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

HMOX1 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Aging, Als, Atherosclerosis. Connected to 258 entities in the SciDEX knowledge graph.

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flowchart TD
    NFE2L2["NFE2L2<br/>(NRF2 gene)"] --|"activates"|--> HMOX1["HMOX1<br/>(Heme Oxygenase-1)"]
    NRF2_protein["NRF2<br/>(protein)"] --|"regulates"|--> HMOX1
    HIF1["HIF1<br/>(pathway)"] --|"activates"|--> HMOX1
    L_reuteri["L. reuteri-CMVs<br/>(therapeutic)"] --|"activates"|--> HMOX1
    
    HMOX1 --|"inhibits"|--> ferroptosis["Ferroptosis<br/>(cell death)"]
    HMOX1 --|"inhibits"|--> inflammation_pheno["Neuroinflammation<br/>(process)"]
    HMOX1 --|"activates"|--> NFE2L2
    HMOX1 --|"activates"|--> ALOX15["ALOX15<br/>(lipoxygenase)"]
    HMOX1 --|"activates"|--> ALOX12["ALOX12<br/>(lipoxygenase)"]
    
    HMOX1 --|"therapeutic_target"|--> MS["Multiple Sclerosis<br/>(MS)"]
    HMOX1 --|"therapeutic_target"|--> Stroke["Stroke<br/>(cerebrovascular)"]
    HMOX1 --|"therapeutic_target"|--> Ischemia["Brain Ischemia<br/>(hypoxia)"]
    HMOX1 --|"associated_with"|--> ALS["Amyotrophic Lateral<br/>Sclerosis (ALS)"]
    HMOX1 --|"regulates"|--> Aging["Neuronal Aging<br/>(senescence)"]
    
    ferroptosis --> neurodegeneration["Neurodegeneration<br/>(outcome)"]
    inflammation_pheno --> neurodegeneration
    MS --> neurodegeneration
    ALS --> neurodegeneration
    
    style HMOX1 fill:#006494
    style ferroptosis fill:#ef5350
    style inflammation_pheno fill:#ef5350
    style neurodegeneration fill:#5d4400
    style NFE2L2 fill:#4a1a6b
    style NRF2_protein fill:#4a1a6b
    style L_reuteri fill:#1b5e20
    style MS fill:#ef5350
    style ALS fill:#ef5350
    style Stroke fill:#ef5350
    style Ischemia fill:#ef5350
    style Aging fill:#5d4400