gene

WNT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections
0Hypotheses
0Analyses
30Outgoing
19Incoming

Summary

Page for WNT1 Gene

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🧬 Gene Info
Gene SymbolWNT1
Chromosome12q13.12
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressiondiscrete regions of the developing and adult brain:
Molecular Weight38 kDa
Amino Acids370 aa
Exons4
PathwaysWnt, WNT
UniProt IDP56746
NCBI Gene ID7471
Ensembl IDENSG00000125084
GeneCardsWNT1
Human Protein AtlasWNT1
RegionExpression Level
[Hippocampus](/brain-regions/hippocampus)High
Associated Diseasesneurodegeneration
Known Drugs/CompoundsIPA
InteractionsCRH, ADRA2B, IL13, CHRNE, WNT11, GRIN3B
KG Connections49 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: WNT1 — AlphaFold P56746 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

WNT1 Gene

gene · 1226 words

Wnt Signaling in Neurodegeneration

mechanism · 3016 words

FZD8 Gene

gene · 2717 words

wnt-beta-catenin-signaling-pathway

mechanism · 2612 words

Wnt Signaling Dysfunction in Neurodegenerative Diseases

mechanism · 2553 words

FZD8 Protein

protein · 2470 words

Pathway Diagram

graph TD
    WNT1["WNT1"]
    Als["Als"]
    ASTROCYTE["ASTROCYTE"]
    CRH["CRH"]
    WNT["WNT"]
    ADRA2B["ADRA2B"]
    IL13["IL13"]
    CHRNE["CHRNE"]
    WNT11["WNT11"]
    GRIN3B["GRIN3B"]
    TNFRSF1B["TNFRSF1B"]
    GABA["GABA"]
    TNFRSF13C["TNFRSF13C"]
    HCRTR1["HCRTR1"]
    CYTOKINES["CYTOKINES"]
    Wnt["Wnt"]
    Microglia["Microglia"]
    Astrocyte["Astrocyte"]
    CHRM4["CHRM4"]
    MYO7A["MYO7A"]
    GRM2["GRM2"]
    WNT1 -->|"activates"| Als
    WNT1 -->|"activates"| ASTROCYTE
    WNT1 -->|"activates"| CRH
    WNT1 -->|"activates"| WNT
    WNT1 -->|"activates"| ADRA2B
    WNT1 -->|"activates"| IL13
    WNT1 -->|"activates"| CHRNE
    WNT1 -->|"activates"| WNT11
    WNT1 -->|"activates"| GRIN3B
    WNT1 -->|"activates"| TNFRSF1B
    WNT1 -->|"activates"| GABA
    WNT1 -->|"activates"| TNFRSF13C
    WNT1 -->|"activates"| HCRTR1
    WNT1 -->|"activates"| CYTOKINES
    WNT1 -->|"activates"| Wnt
    WNT1 -->|"activates"| Microglia
    WNT1 -->|"activates"| Astrocyte
    CHRM4 -->|"activates"| WNT1
    MYO7A -->|"activates"| WNT1
    GRM2 -->|"activates"| WNT1
    style WNT1 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (30)

TargetRelationTypeStr
STAT3activatesprotein0.85
Alsactivatesdisease0.65
ALSactivatesdisease0.65
CRHactivatesgene0.60
ADRA2Bactivatesgene0.60

Incoming (19)

SourceRelationTypeStr
IPAinhibitscompound0.95
CHRM4activatesgene0.60
MYO7Aactivatesgene0.60
GRM2activatesgene0.60
CRHactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found