Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about WNT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | WNT1 |
| Chromosome | 12q13.12 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | discrete regions of the developing and adult brain: |
| Molecular Weight | 38 kDa |
| Amino Acids | 370 aa |
| Exons | 4 |
| Pathways | Wnt, WNT |
| UniProt ID | P56746 |
| NCBI Gene ID | 7471 |
| Ensembl ID | ENSG00000125084 |
| GeneCards | WNT1 |
| Human Protein Atlas | WNT1 |
| Region | Expression Level |
| [Hippocampus](/brain-regions/hippocampus) | High |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | IPA |
| Interactions | CRH, ADRA2B, IL13, CHRNE, WNT11, GRIN3B |
| KG Connections | 49 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
WNT1["WNT1"]
Als["Als"]
ASTROCYTE["ASTROCYTE"]
CRH["CRH"]
WNT["WNT"]
ADRA2B["ADRA2B"]
IL13["IL13"]
CHRNE["CHRNE"]
WNT11["WNT11"]
GRIN3B["GRIN3B"]
TNFRSF1B["TNFRSF1B"]
GABA["GABA"]
TNFRSF13C["TNFRSF13C"]
HCRTR1["HCRTR1"]
CYTOKINES["CYTOKINES"]
Wnt["Wnt"]
Microglia["Microglia"]
Astrocyte["Astrocyte"]
CHRM4["CHRM4"]
MYO7A["MYO7A"]
GRM2["GRM2"]
WNT1 -->|"activates"| Als
WNT1 -->|"activates"| ASTROCYTE
WNT1 -->|"activates"| CRH
WNT1 -->|"activates"| WNT
WNT1 -->|"activates"| ADRA2B
WNT1 -->|"activates"| IL13
WNT1 -->|"activates"| CHRNE
WNT1 -->|"activates"| WNT11
WNT1 -->|"activates"| GRIN3B
WNT1 -->|"activates"| TNFRSF1B
WNT1 -->|"activates"| GABA
WNT1 -->|"activates"| TNFRSF13C
WNT1 -->|"activates"| HCRTR1
WNT1 -->|"activates"| CYTOKINES
WNT1 -->|"activates"| Wnt
WNT1 -->|"activates"| Microglia
WNT1 -->|"activates"| Astrocyte
CHRM4 -->|"activates"| WNT1
MYO7A -->|"activates"| WNT1
GRM2 -->|"activates"| WNT1
style WNT1 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px| Target | Relation | Type | Str |
|---|---|---|---|
| STAT3 | activates | protein | 0.85 |
| Als | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| CRH | activates | gene | 0.60 |
| ADRA2B | activates | gene | 0.60 |
| IL13 | activates | gene | 0.60 |
| CHRNE | activates | gene | 0.60 |
| WNT11 | activates | gene | 0.60 |
| GRIN3B | activates | gene | 0.60 |
| TNFRSF1B | activates | gene | 0.60 |
| TNFRSF13C | activates | gene | 0.60 |
| HCRTR1 | activates | gene | 0.60 |
| MYO7A | activates | gene | 0.60 |
| CHRM4 | activates | gene | 0.60 |
| GRM2 | activates | gene | 0.60 |
| Rb | activates | protein | 0.60 |
| ASTROCYTE | activates | gene | 0.60 |
| WNT | activates | gene | 0.60 |
| GABA | activates | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| Wnt | activates | pathway | 0.60 |
| Microglia | activates | cell_type | 0.60 |
| Astrocyte | activates | cell_type | 0.60 |
| AND | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| Cytokine | activates | protein | 0.60 |
| Brainstem | expressed_in | brain_region | 0.55 |
| Astrocyte | expressed_in | cell_type | 0.55 |
| Microglia | expressed_in | cell_type | 0.55 |
| WNT SIGNALING | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| IPA | inhibits | compound | 0.95 |
| CHRM4 | activates | gene | 0.60 |
| MYO7A | activates | gene | 0.60 |
| GRM2 | activates | gene | 0.60 |
| CRH | activates | gene | 0.60 |
| IL13 | activates | gene | 0.60 |
| TNFRSF13C | activates | gene | 0.60 |
| CHRNE | activates | gene | 0.60 |
| ADRA2B | activates | gene | 0.60 |
| GRIN3B | activates | gene | 0.60 |
| HCRTR1 | activates | gene | 0.60 |
| TNFRSF1B | activates | gene | 0.60 |
| WNT | activates | gene | 0.60 |
| GABA | activates | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| ASTROCYTE | activates | gene | 0.60 |
| WNT SIGNALING | expressed_in | pathway | 0.55 |
| WNT11 | activates | gene | 0.50 |
| WNT SIGNALING | associated_with | pathway | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||