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entity

M1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about M1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections
10Hypotheses
2Analyses
1Outgoing
1Incoming
0Experiments
2Debates

No AI portrait yet

Wiki Pages (20)

Knowledge base pages for this entity

SQSTM1 — Sequestosome 1 (p62)

gene · 3742 words
→

KRIT1 — Krev Interaction Trapped 1 (CCM1)

gene · 3621 words
→

AIFM1 Gene

gene · 3251 words
→

AP2M1 Gene

gene · 3193 words
→

TMEM175 Protein

protein · 2968 words
→

Outgoing (1)

TargetRelationTypeStr
PI3K-AKTactivatespathway0.80

Incoming (1)

SourceRelationTypeStr
TLR4activatesprotein0.70

Targeting Hypotheses (10)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-D 0.698 neurodegeneration What is the molecular mechanism by which
TREM2 Agonism Has Narrow Early-Window at DAM1→DAM2 Transitio 0.668 neurodegeneration What is the optimal therapeutic window f
Pharmacologic SARM1 blockade to prevent Wallerian degenerati 0.660 neurodegeneration Test
M1 Muscarinic Receptor Agonism as Pharmacological Exercise S 0.589 neurodegeneration What are the specific circulating factor
NAD+/SARM1 Axis Provides Metabolic Feedback Coupling Mitopha 0.578 neurodegeneration How do different organelle-specific auto
Disrupting Muscarinic M1/M3 Receptor-Mediated Tau Internaliz 0.550 neuroscience Trans-synaptic tau spreading and propaga
GM1 Ganglioside Reduction via ST3GAL5 Activation to Block Aβ 0.454 lipidomics Lipid metabolism dysregulation in Alzhei
CHIP-mediated K63-linked ubiquitination redirects oligomeric 0.380 protein-biochemistry Do chaperones selectively recognize path
CHIP-mediated K63-linked ubiquitination promotes autophagoso 0.380 protein-biochemistry Do chaperones selectively recognize path
Astrocytic SQSTM1 Overexpression Therapy 0.000 - How do non-cell autonomous effects of au

Mentioning Analyses (2)

Scientific analyses that reference this entity

What determines the spatial organization of autophagy receptors at stress granul

neurodegeneration | 2026-04-08 | 5 hypotheses Top: 0.633

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.380

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (2)

Multi-agent debates referencing this entity

SQSTM1 and CALCOCO2 specifically localize to SG periphery rather than throughout

closed · Rounds: 4 · Score: 0.69 · 2026-04-21

How do alterations in brain lipid metabolism—including gangliosides, phospholipi

closed · Rounds: 4 · Score: 0.84 · 2026-04-11

Related Research

Hypotheses and analyses mentioning M1 in their description or question text

Disrupting Muscarinic M1/M3 Receptor-Mediated Tau Internalization and Synaptic T

Score: 0.550 · neuroscience · 2026-04-22

## Mechanistic Overview Disrupting Muscarinic M1/M3 Receptor-Mediated Tau Internalization and Synaptic Targeting starts

GM1 Ganglioside Reduction via ST3GAL5 Activation to Block Aβ Oligomerization See

Score: 0.454 · lipidomics · 2026-04-25

GM1 Ganglioside Reduction via ST3GAL5 Activation to Block Aβ Oligomerization Seeds

CHIP-mediated K63-linked ubiquitination redirects oligomeric pathologic conforme

Score: 0.380 · protein-biochemistry · 2026-04-27

**Molecular Mechanism and Rationale** The carboxy terminus of Hsc70-interacting protein (CHIP, encoded by STUB1) functi

CHIP-mediated K63-linked ubiquitination promotes autophagosomal sequestration of

Score: 0.380 · protein-biochemistry · 2026-04-27

The carboxy terminus of Hsc70-interacting protein (CHIP, encoded by STUB1) functions as a dual-specificity E3 ubiquitin

Astrocytic SQSTM1 Overexpression Therapy

Score: 0.000 · unknown disease · 2026-04-28

Enhancing SQSTM1/p62 expression in astrocytes to create cellular sinks for misfolded proteins released from dying motor

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