protein

MAOBPROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about MAOBPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	MAOBPROTEIN
Full Name	B (Monoamine Oxidase B) Protein
Protein Type	Enzyme
Function	is a mitochondrial flavin adenine dinucleotide (FAD)-dependent enzyme that preferentially metabolizes phenylethylamine, benzylamine, and dopamine.
Primary Expression	Brain (astrocytes, substantia nigra), peripheral tissues
Subcellular Localization	</strong></td><td>Mitochondrial outer membrane</td></tr>
Molecular Weight	~58 kDa (520 amino acids)
Amino Acids	520 aa
UniProt ID	P27338
GeneCards	MAOBPROTEIN
Human Protein Atlas	MAOBPROTEIN
FAD-binding domain (residues 1-206)	Contains the catalytic core with covalently bound FAD cofactor at position 397[@de2005]
C-terminal transmembrane helix	Anchors the enzyme to the mitochondrial outer membrane
Phenylethylamine-binding site	High affinity for phenylethylamine (Km ~ 20 µM)
Ile199 residue	Key determinant of B-selective inhibitors
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Anxiety, Dementia
Interactions	AKT1, APP, BCL2, CASP3, GENES, GSK3B
KG Connections	157 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MAOBPROTEIN — AlphaFold P27338 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MAOB Protein

protein · 1034 words

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Pathway Diagram

graph TD
    MAOBPROTEIN["MAOBPROTEIN"]
    neurodegeneration["neurodegeneration"]
    MAOBPROTEIN -->|"implicated_in"| neurodegeneration
    style MAOBPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning MAOBPROTEIN in their description or question text

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