Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MAP2K2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive coverage of MAP2K2 (MEK2) kinase in MAPK signaling, synaptic plasticity, and neurodegenerative diseases including AD/PD
| Gene Symbol | MAP2K2 |
| Full Name | MAP2K2 |
| Chromosome | 19p13.3 |
| Protein Type | Gene |
| Function | encodes a dual-specificity serine/threonine kinase that plays a central role in the RAS-RAF-MEK-ERK (MAPK) signaling cascade. |
| Molecular Weight | 44 kDa |
| Amino Acids | 400 aa |
| Exons | 11 |
| Pathways | MAPK, MAPK pathway |
| NCBI Gene ID | Search NCBI |
| GeneCards | MAP2K2 |
| Human Protein Atlas | MAP2K2 |
| Associated Diseases | neurodegeneration |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
MAP2K2["MAP2K2"]
ATM["ATM"]
MAP2K2 -->|"expressed_in"| ATM
FOXP3["FOXP3"]
MAP2K2 -->|"expressed_in"| FOXP3
TP53["TP53"]
MAP2K2 -->|"expressed_in"| TP53
PD_L1["PD-L1"]
MAP2K2 -->|"expressed_in"| PD_L1
RB1["RB1"]
MAP2K2 -->|"expressed_in"| RB1
CD8["CD8"]
MAP2K2 -->|"expressed_in"| CD8
PTEN["PTEN"]
MAP2K2 -->|"expressed_in"| PTEN
PIK3CA["PIK3CA"]
MAP2K2 -->|"expressed_in"| PIK3CA
PD_1["PD-1"]
MAP2K2 -->|"expressed_in"| PD_1
TSC1["TSC1"]
MAP2K2 -->|"expressed_in"| TSC1
KMT2A["KMT2A"]
MAP2K2 -->|"expressed_in"| KMT2A
CDKN2A["CDKN2A"]
CDKN2A -->|"expressed_in"| MAP2K2
neurodegeneration["neurodegeneration"]
MAP2K2 -->|"implicated_in"| neurodegeneration| Source | Relation | Type | Str |
|---|---|---|---|
| CDKN2A | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||