protein

MAPK1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

MAPK1 (Mitogen-Activated Protein Kinase 1), also known as ERK2 (Extracellular Signal-Regulated Kinase 2), is a member of the MAP kinase family that plays central roles in cellular signaling, neuronal function, and disease pathogenesis.

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🔬 Protein Info

Gene Symbol	MAPK1PROTEIN
Full Name	Mitogen-Activated Protein Kinase 1 / Extracellular Signal-Regulated Kinase 2
Chromosome	22q11.21
Protein Family	MAP kinase family (MAPK/ERK)
Protein Type	Kinase
Function	Serine/Threonine Kinase, cell signaling
Molecular Weight	41.4 kDa (ERK2 isoform)
Exons	9
GeneCards	MAPK1PROTEIN
Human Protein Atlas	MAPK1PROTEIN
Neurons	High expression in cortex, hippocampus, and cerebellum
Glia	Expression in astrocytes and microglia
Synapses	Postsynaptic density localization
Development	Higher expression during neurodevelopment
Associated Diseases	Aging, Als, Alzheimer, Cancer, Carcinoma
Known Drugs/Compounds	Chrysotoxine, DEP, DMP, DOP, Zuojin Pill
Interactions	ACTB, ACTG1, Actin, ACVR1, AIFM1, AKT
KG Connections	946 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

mapk1-protein

protein · 1522 words

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Pathway Diagram

graph TD
    MAPK1PROTEIN["MAPK1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    MAPK1PROTEIN -->|"implicated_in"| neurodegeneration
    style MAPK1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity