gene

P2RX5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2RX5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections
0Hypotheses
0Analyses
25Outgoing
20Incoming

Summary

P2RX5 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, implicated in. Associated with ALS, Als, Covid. Connected to 27 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolP2RX5
Chromosome17p13.1
Protein TypeChannel
Functionencodes a member of the P2X family of ATP-gated ion channels.
Primary Expressionvarious tissues including lymphoid organs, bladder, and parts of the nervous system, with roles in immune function, sensory signaling, and more recent
Amino Acids422 aa
NCBI Gene ID5026
GeneCardsP2RX5
Human Protein AtlasP2RX5
Official SymbolP2RX5
Official Full NamePurinergic Receptor P2X Ligand-Gated Ion Channel 5
Protein ClassLigand-gated ion channel
Protein Length422 amino acids
Associated DiseasesALS, Inflammation
InteractionsPANX1, P2RY12, P2RX7, P2RX4, ADORA2B, P2RX1
KG Connections45 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

P2RX5 Gene

gene · 1021 words

P2X5 Receptor Protein

protein · 672 words

PANX1 Protein

protein · 646 words

PANX1 Gene

gene · 529 words

Proteins

index · 296 words

Genes

index · 271 words

Pathway Diagram

graph TD
    P2RX5["<b>P2RX5</b>"]
    Als{"Als"}
    P2RX5 -->|"associated with"| Als
    Inflammation{"Inflammation"}
    P2RX5 -->|"associated with"| Inflammation
    Covid{"Covid"}
    P2RX5 -->|"activates"| Covid
    ALS{"ALS"}
    P2RX5 -->|"associated with"| ALS
    PANX1["PANX1"]
    P2RX5 -->|"activates"| PANX1
    P2RY12["P2RY12"]
    P2RX5 -->|"activates"| P2RY12
    INFLAMMATION["INFLAMMATION"]
    P2RX5 -->|"associated with"| INFLAMMATION
    P2RX7["P2RX7"]
    P2RX5 -->|"activates"| P2RX7
    P2RX4["P2RX4"]
    P2RX5 -->|"activates"| P2RX4
    GENES["GENES"]
    P2RX5 -->|"activates"| GENES
    CD38["CD38"]
    P2RX5 -->|"associated with"| CD38
    ATP["ATP"]
    P2RX5 -->|"associated with"| ATP
    ADORA2B["ADORA2B"]
    ADORA2B -->|"activates"| P2RX5
    P2RY12 -->|"activates"| P2RX5
    P2RX1["P2RX1"]
    P2RX1 -->|"activates"| P2RX5
    P2RX4 -->|"activates"| P2RX5
    P2RX7 -->|"activates"| P2RX5
    CD38 -->|"associated with"| P2RX5
    P2RY1["P2RY1"]
    P2RY1 -->|"activates"| P2RX5
    PANX1 -->|"activates"| P2RX5
    GENES -->|"activates"| P2RX5
    ATP -->|"associated with"| P2RX5
    NAD["NAD"]
    NAD -->|"associated with"| P2RX5
    AND["AND"]
    AND -->|"activates"| P2RX5
    style P2RX5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

TargetRelationTypeStr
UPREGULATESupregulatesentity0.95
Alsassociated_withdisease0.65
Inflammationassociated_withdisease0.65
Covidactivatesdisease0.65
ALSassociated_withdisease0.65

Incoming (20)

SourceRelationTypeStr
ADORA2Bactivatesgene0.60
P2RY12activatesgene0.60
P2RX1activatesgene0.60
P2RX4activatesgene0.60
P2RX7activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found