Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about P2RX5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
P2RX5 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, implicated in. Associated with ALS, Als, Covid. Connected to 27 entities in the SciDEX knowledge graph.
| Gene Symbol | P2RX5 |
| Chromosome | 17p13.1 |
| Protein Type | Channel |
| Function | encodes a member of the P2X family of ATP-gated ion channels. |
| Primary Expression | various tissues including lymphoid organs, bladder, and parts of the nervous system, with roles in immune function, sensory signaling, and more recent |
| Amino Acids | 422 aa |
| NCBI Gene ID | 5026 |
| GeneCards | P2RX5 |
| Human Protein Atlas | P2RX5 |
| Official Symbol | P2RX5 |
| Official Full Name | Purinergic Receptor P2X Ligand-Gated Ion Channel 5 |
| Protein Class | Ligand-gated ion channel |
| Protein Length | 422 amino acids |
| Associated Diseases | ALS, Inflammation |
| Interactions | PANX1, P2RY12, P2RX7, P2RX4, ADORA2B, P2RX1 |
| KG Connections | 45 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
P2RX5["<b>P2RX5</b>"]
Als{"Als"}
P2RX5 -->|"associated with"| Als
Inflammation{"Inflammation"}
P2RX5 -->|"associated with"| Inflammation
Covid{"Covid"}
P2RX5 -->|"activates"| Covid
ALS{"ALS"}
P2RX5 -->|"associated with"| ALS
PANX1["PANX1"]
P2RX5 -->|"activates"| PANX1
P2RY12["P2RY12"]
P2RX5 -->|"activates"| P2RY12
INFLAMMATION["INFLAMMATION"]
P2RX5 -->|"associated with"| INFLAMMATION
P2RX7["P2RX7"]
P2RX5 -->|"activates"| P2RX7
P2RX4["P2RX4"]
P2RX5 -->|"activates"| P2RX4
GENES["GENES"]
P2RX5 -->|"activates"| GENES
CD38["CD38"]
P2RX5 -->|"associated with"| CD38
ATP["ATP"]
P2RX5 -->|"associated with"| ATP
ADORA2B["ADORA2B"]
ADORA2B -->|"activates"| P2RX5
P2RY12 -->|"activates"| P2RX5
P2RX1["P2RX1"]
P2RX1 -->|"activates"| P2RX5
P2RX4 -->|"activates"| P2RX5
P2RX7 -->|"activates"| P2RX5
CD38 -->|"associated with"| P2RX5
P2RY1["P2RY1"]
P2RY1 -->|"activates"| P2RX5
PANX1 -->|"activates"| P2RX5
GENES -->|"activates"| P2RX5
ATP -->|"associated with"| P2RX5
NAD["NAD"]
NAD -->|"associated with"| P2RX5
AND["AND"]
AND -->|"activates"| P2RX5
style P2RX5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| UPREGULATES | upregulates | entity | 0.95 |
| Als | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Covid | activates | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| PANX1 | activates | gene | 0.60 |
| P2RY12 | activates | gene | 0.60 |
| P2RX7 | activates | gene | 0.60 |
| P2RX4 | activates | gene | 0.60 |
| CD38 | associated_with | gene | 0.60 |
| ADORA2B | activates | gene | 0.60 |
| P2RX1 | activates | gene | 0.60 |
| P2RX7 | regulates | entity | 0.60 |
| P2RY1 | regulates | entity | 0.60 |
| P2RY12 | regulates | entity | 0.60 |
| PANX1 | regulates | entity | 0.60 |
| P2RY1 | activates | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| ATP | associated_with | gene | 0.60 |
| NAD | associated_with | gene | 0.60 |
| App | associated_with | protein | 0.60 |
| P2RX7 | co_expressed_with | gene | 0.50 |
| P2RY1 | co_expressed_with | gene | 0.50 |
| GENE EXPRESSION | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ADORA2B | activates | gene | 0.60 |
| P2RY12 | activates | gene | 0.60 |
| P2RX1 | activates | gene | 0.60 |
| P2RX4 | activates | gene | 0.60 |
| P2RX7 | activates | gene | 0.60 |
| CD38 | associated_with | gene | 0.60 |
| P2RY1 | activates | gene | 0.60 |
| PANX1 | activates | gene | 0.60 |
| ADORA2B | regulates | entity | 0.60 |
| P2RX1 | regulates | entity | 0.60 |
| P2RX4 | regulates | entity | 0.60 |
| F3 | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| ATP | associated_with | gene | 0.60 |
| NAD | associated_with | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| AND | activates | gene | 0.60 |
| P2RX1 | co_expressed_with | gene | 0.50 |
| P2RX4 | co_expressed_with | gene | 0.50 |
| adora2b | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||