Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Covid: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | CD38, AND, PPAR, GENES, HIF, ROS, CANCER, RAGE |
| KG Connections | 132 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Covid["Covid"] -->|"therapeutic target"| Autophagy["Autophagy"]
Covid["Covid"] -->|"regulates"| Apoptosis["Apoptosis"]
Covid["Covid"] -->|"activates"| Cell_Cycle["Cell Cycle"]
Covid["Covid"] -.->|"inhibits"| Lipid_Metabolism["Lipid Metabolism"]
Covid["Covid"] -.->|"inhibits"| Ferroptosis["Ferroptosis"]
Covid["Covid"] -.->|"inhibits"| Apoptosis_1["Apoptosis"]
ADORA2B["ADORA2B"] -->|"activates"| Covid["Covid"]
CD38["CD38"] -->|"associated"| Covid["Covid"]
P2RX1["P2RX1"] -->|"activates"| Covid["Covid"]
P2RX4["P2RX4"] -->|"activates"| Covid["Covid"]
style Covid fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Autophagy | therapeutic_target | pathway | 0.55 |
| Apoptosis | regulates | pathway | 0.55 |
| Cell Cycle | activates | pathway | 0.55 |
| Lipid Metabolism | inhibits | pathway | 0.55 |
| Ferroptosis | inhibits | pathway | 0.55 |
| Apoptosis | inhibits | pathway | 0.55 |
| Mitochondrial Function | inhibits | pathway | 0.55 |
| Inflammasome | associated_with | pathway | 0.55 |
| Phagocytosis | associated_with | pathway | 0.55 |
| Apoptosis | therapeutic_target | pathway | 0.55 |
| Akt | therapeutic_target | pathway | 0.55 |
| Immune Response | therapeutic_target | pathway | 0.55 |
| Jak-Stat | therapeutic_target | pathway | 0.55 |
| Adaptive Immunity | therapeutic_target | pathway | 0.55 |
| Innate Immunity | therapeutic_target | pathway | 0.55 |
| Hedgehog | interacts_with | pathway | 0.55 |
| Toll-Like Receptor | interacts_with | pathway | 0.55 |
| Calcium Signaling | interacts_with | pathway | 0.55 |
| Nf-Κb | interacts_with | pathway | 0.55 |
| Akt | associated_with | pathway | 0.55 |
| Pi3K | associated_with | pathway | 0.55 |
| Mapk | associated_with | pathway | 0.55 |
| GENE EXPRESSION | expressed_in | concept | 0.50 |
| Proteins | activates | protein | 0.50 |
| GENE EXPRESSION | activates | concept | 0.50 |
| Proteins | associated_with | protein | 0.50 |
| Proteins | interacts_with | protein | 0.50 |
| LEWY BODY | regulates | concept | 0.50 |
| NUCLEUS | regulates | concept | 0.50 |
| CEREBROSPINAL FLUID | interacts_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ADORA2B | activates | gene | 0.65 |
| CD38 | associated_with | gene | 0.65 |
| P2RX1 | activates | gene | 0.65 |
| P2RX4 | activates | gene | 0.65 |
| P2RX5 | activates | gene | 0.65 |
| P2RX7 | activates | gene | 0.65 |
| P2RY1 | activates | gene | 0.65 |
| P2RY12 | activates | gene | 0.65 |
| PANX1 | activates | gene | 0.65 |
| EGFR | activates | gene | 0.65 |
| STAT1 | activates | gene | 0.65 |
| STAT3 | activates | gene | 0.65 |
| TLR4 | activates | gene | 0.65 |
| AND | therapeutic_target | gene | 0.65 |
| AUTOPHAGY | therapeutic_target | gene | 0.65 |
| APOPTOSIS | regulates | gene | 0.65 |
| AND | regulates | gene | 0.65 |
| MITOCHONDRIAL DYSFUNCTION | regulates | gene | 0.65 |
| GENES | regulates | gene | 0.65 |
| DNA | regulates | gene | 0.65 |
| MMP9 | regulates | gene | 0.65 |
| GPX4 | inhibits | gene | 0.65 |
| HIF-1Α | inhibits | gene | 0.65 |
| APOPTOSIS | inhibits | gene | 0.65 |
| AND | associated_with | gene | 0.65 |
| BAX | inhibits | gene | 0.65 |
| PPAR | associated_with | gene | 0.65 |
| GENES | associated_with | gene | 0.65 |
| HIF | associated_with | gene | 0.65 |
| ROS | associated_with | gene | 0.65 |
| CANCER | associated_with | gene | 0.65 |
| RAGE | associated_with | gene | 0.65 |
| BCL2 | inhibits | gene | 0.65 |
| FERROPTOSIS | inhibits | gene | 0.65 |
| INFLAMMATION | associated_with | gene | 0.65 |
| CX3CL1 | associated_with | gene | 0.65 |
| MICROGLIA | associated_with | gene | 0.65 |
| CX3CR1 | associated_with | gene | 0.65 |
| SYNAPSE | associated_with | gene | 0.65 |
| MYELIN | associated_with | gene | 0.65 |
| IL-6 | associated_with | gene | 0.65 |
| PHAGOCYTOSIS | associated_with | gene | 0.65 |
| AND | activates | gene | 0.65 |
| IL-6 | activates | gene | 0.65 |
| APOPTOSIS | therapeutic_target | gene | 0.65 |
| AKT1 | therapeutic_target | gene | 0.65 |
| GENES | therapeutic_target | gene | 0.65 |
| CYTOKINES | therapeutic_target | gene | 0.65 |
| JAK | inhibits | gene | 0.65 |
| AND | inhibits | gene | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||