Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Pancreatic Cancer: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | TSPAN1, MCOLN1, TAZ, KRAS, RAS, CANCER, YAP, GENES |
| Therapeutic Agents | Zalcitabine, ZALCITABINE |
| KG Connections | 471 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Pancreatic_Cancer["<b>Pancreatic Cancer</b>"]
Cancer{"Cancer"}
Pancreatic_Cancer -->|"therapeutic_target"| Cancer
Carcinoma{"Carcinoma"}
Pancreatic_Cancer -->|"activates"| Carcinoma
Autophagy["Autophagy"]
Pancreatic_Cancer -->|"therapeutic_target"| Autophagy
Tumor{"Tumor"}
Pancreatic_Cancer -->|"activates"| Tumor
CANCER(["CANCER"])
CANCER -->|"associated_with"| Pancreatic_Cancer
AUTOPHAGY(["AUTOPHAGY"])
AUTOPHAGY -->|"therapeutic_target"| Pancreatic_Cancer
style Pancreatic_Cancer fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | therapeutic_target | disease | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Cancer | associated_with | disease | 0.95 |
| Tumor | activates | disease | 0.95 |
| Tumor | inhibits | disease | 0.95 |
| Digestive System Cancers | associated_with | disease | 0.80 |
| Tumor Microenvironment | therapeutic_target | pathway | 0.80 |
| Autophagy | activates | pathway | 0.80 |
| Ferroptosis | activates | pathway | 0.80 |
| Tumor Microenvironment | activates | pathway | 0.80 |
| Apoptosis | inhibits | pathway | 0.80 |
| Carcinoma | associated_with | disease | 0.75 |
| Cancer | causes | disease | 0.75 |
| Cancer | inhibits | disease | 0.75 |
| Cancer | regulates | disease | 0.75 |
| Cancer | biomarker_for | disease | 0.75 |
| Apoptosis | activates | pathway | 0.70 |
| Invasion | therapeutic_target | pathway | 0.70 |
| Metastasis | therapeutic_target | pathway | 0.70 |
| Notch | therapeutic_target | pathway | 0.70 |
| Wnt | therapeutic_target | pathway | 0.70 |
| Ferroptosis | therapeutic_target | pathway | 0.70 |
| Tumor Microenvironment | regulates | pathway | 0.70 |
| Nf-Κb | activates | pathway | 0.70 |
| Autophagy | inhibits | pathway | 0.70 |
| Mapk | regulates | pathway | 0.70 |
| Tumor Microenvironment | implicated_in | pathway | 0.70 |
| Metastasis | activates | pathway | 0.70 |
| Tumor | associated_with | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Gastric Cancer | therapeutic_target | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Hippo Pathway | associated_with | pathway | 0.60 |
| Chemoresistance | associated_with | pathway | 0.60 |
| Pi3K/Akt | therapeutic_target | pathway | 0.60 |
| Cell Cycle | activates | pathway | 0.60 |
| Angiogenesis | therapeutic_target | pathway | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| Epigenetic | therapeutic_target | pathway | 0.60 |
| Metastasis | associated_with | pathway | 0.60 |
| Cell Cycle | regulates | pathway | 0.60 |
| Nf-Κb | therapeutic_target | pathway | 0.60 |
| Immune Response | therapeutic_target | pathway | 0.60 |
| Mitophagy | therapeutic_target | pathway | 0.60 |
| Apoptosis | causes | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CANCER | associated_with | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| TSPAN1 | associated_with | gene | 0.95 |
| CANCER | inhibits | gene | 0.95 |
| CANCER | regulates | gene | 0.95 |
| PRMT1 | promotes | gene | 0.95 |
| PRMT1 | expressed_in | protein | 0.90 |
| TSPAN1 | expressed_in | gene | 0.90 |
| Zalcitabine | treats | drug | 0.90 |
| ANXA1 | associated_with | protein | 0.90 |
| Ferroptosis | suppresses | process | 0.90 |
| Tspan1 | drives | protein | 0.90 |
| ANXA1 | biomarker_for | protein | 0.85 |
| MCOLN1 | targets | protein | 0.85 |
| GENES | associated_with | gene | 0.85 |
| AUTOPHAGY | activates | gene | 0.85 |
| CANCER | expressed_in | gene | 0.85 |
| KRAS | inhibits | gene | 0.85 |
| FERROPTOSIS | activates | gene | 0.85 |
| CANCER | causes | gene | 0.85 |
| INFLAMMATION | associated_with | gene | 0.85 |
| Tumor | regulates | disease | 0.85 |
| Carcinoma | regulates | disease | 0.85 |
| APOPTOSIS | inhibits | gene | 0.85 |
| Cancer | associated_with | disease | 0.85 |
| CANCER | biomarker_for | gene | 0.85 |
| Mitochondrial Fission | associated_with | process | 0.85 |
| ZALCITABINE | treats | drug | 0.85 |
| MCOLN1 | associated_with | protein | 0.80 |
| CD68+ Macrophages | associated_with | cell_type | 0.80 |
| Cleaved Caspase-3 | biomarker_for | biomarker | 0.80 |
| TSPAN1 | therapeutic_target | gene | 0.80 |
| KRAS | associated_with | gene | 0.75 |
| APOPTOSIS | activates | gene | 0.75 |
| Tumor | therapeutic_target | disease | 0.75 |
| Als | therapeutic_target | disease | 0.75 |
| Carcinoma | therapeutic_target | disease | 0.75 |
| INFLAMMATION | therapeutic_target | gene | 0.75 |
| CD44 | therapeutic_target | gene | 0.75 |
| INFLAMMATION | activates | gene | 0.75 |
| FERROPTOSIS | therapeutic_target | gene | 0.75 |
| KRAS | regulates | gene | 0.75 |
| Inflammation | associated_with | disease | 0.75 |
| NF-ΚB | activates | gene | 0.75 |
| ERK | activates | gene | 0.75 |
| AUTOPHAGY | inhibits | gene | 0.75 |
| GENES | activates | gene | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||