entity

PGC1Α

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PGC1Α: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections

5Hypotheses

3Analyses

21Outgoing

11Incoming

11Experiments

12Debates

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Outgoing (21)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PGC1Α	data_in	dataset_row	0.00
h-var-5c4b90eeeb	targeted_by	hypothesis	1.00
BACE1	regulates	entity	0.95
MITOCHONDRIAL BIOGENESIS	regulates	entity	0.95
ALZHEIMER'S DISEASE	associated_with	entity	0.95
ALZHEIMER'S DISEASE	therapeutic_target	entity	0.95
NEURODEGENERATION	protects_against	entity	0.90
MITOCHONDRIAL_BIOGENESIS	regulates	gene	0.90
ROS	regulates	entity	0.90
NEUROINFLAMMATION	regulates	entity	0.90
TFAM	activates	protein	0.90
mitochondrial biogenesis	regulates	process	0.90
mitochondrial biogenesis pathway	activates	pathway	0.90
NRF1/2	activates	protein	0.90
Alzheimer's disease	implicated_in	disease	0.80
MITOCHONDRIAL_FUNCTION	activates	phenotype	0.72
MT-CO2	regulates	gene	0.70
mitochondrial gene transcription	regulates	process	0.70
MT-ND4L	regulates	gene	0.70
MT-ATP6	regulates	gene	0.70
ERRα	activates	protein	0.64

Incoming (11)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PGC1Α	data_in	dataset_row	0.00
h-var-5c4b90eeeb	targets	hypothesis	1.00
MST1	interacts_with	gene	0.95
26363853	induces balanced expression of	paper	0.90
26363853	exerts neuroprotective effects by promoting	paper	0.90
26363853	induces balanced expression of by binding to promoters of	paper	0.90
26363853	controls	paper	0.90
SIRT1	activates	enzyme	0.90
PPARGC1A	encodes	gene	0.80
MST1	interacts_with	protein	0.70
SIRT1	regulates	gene	0.70

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
LRRK2 Volume Sensor Hijacking Drives Metabolic Dysregulation	0.666	neurodegeneration	Does LRRK2's role as a lysosomal volume
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling	0.622	neurodegeneration	Gene expression changes in aging mouse b
PGC1α Activation in PV+ Interneurons Bypasses Mitophagy Defi	0.455	neurodegeneration	Why does PRKN-mediated mitophagy, typica
Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis	0.380	developmental-neurobiology	Do perinatal immune challenges create pe
Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis	0.351	developmental-neurobiology	Do perinatal immune challenges create pe

Mentioning Analyses (3)

Scientific analyses that reference this entity

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 16 hypotheses Top: 0.779

Senescent cell clearance as neurodegeneration therapy

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.769

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-02 | 0 hypotheses

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Transcriptome sequencing of cardiac fibroblasts in TFEB overexpressing	exploratory	myocardial infarction	0.900	R26-LSL-TFEB+/+; Acta2-cre mic	proposed	N/A
Trehalose-induced lysosomal changes and TFEB activation	exploratory	motoneuron degeneration	0.900	NSC34 neuroblastoma x spinal c	proposed	N/A
Trehalose-induced lysosomal membrane permeabilization and TFEB activat	exploratory	motoneuron degeneration	0.900	NSC34 neuroblastoma cells	proposed	N/A
PGC-1α knockout effects on PV+ interneuron maturation	validation		0.900	PGC-1α knockout mice	proposed	N/A
TFEB silencing and misfolded protein degradation	exploratory	motoneuron degeneration	0.880	NSC34 neuroblastoma x spinal c	proposed	N/A
Protein expression analysis and cell migration assays in cardiac fibro	exploratory	cardiac fibrosis	0.880	primary cardiac fibroblasts fr	proposed	N/A
Functional validation of trehalose effects on misfolded protein cleara	exploratory	motoneuron degeneration diseas	0.850	cell models expressing misfold	proposed	N/A
ChIP-qPCR validation of TFEB binding to Thbs1 promoter	exploratory	cardiac fibrosis	0.850	mouse cardiac fibroblasts	proposed	N/A
Trehalose analog testing for autophagy induction	exploratory	motoneuron degeneration	0.820	NSC34 neuroblastoma x spinal c	proposed	N/A
PGC-1α expression analysis during PV+ interneuron development	exploratory		0.800	mouse cortex	proposed	N/A
Activity-dependent regulation of PGC-1α in PV+ interneurons	exploratory		0.800	mouse cortical neurons	proposed	N/A

Related Papers (8)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020]	Chua JP, De Calbiac H, Kabashi E, Barmad	Autophagy	2022	2
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of [PMID:30335591]	Rusmini P, Cortese K, Crippa V, Cristofa	Autophagy	2019	2
Longitudinal modeling of human neuronal aging reveals the contribution of the RC [PMID:38066314]	["Lee S", "Oh Y", "Victor M", "Yang Y",	Nature aging	2024	0
Harlequin syndrome associated with thoracic epidural anaesthesia. [PMID:35118419]	Persson RM, Tellnes K, Hoven H, Haaverst	Anaesthesia reports	2022	0
Transmission dynamics of a linear vanA-plasmid during a nosocomial multiclonal o [PMID:34285270]	Fujiya Y, Harada T, Sugawara Y, Akeda Y,	Scientific reports	2021	0
High resolution spatiotemporal patterns of seawater temperatures across the Beli [PMID:33199700]	Helmuth B, Leichter JJ, Rotjan RD, Casti	Scientific data	2020	0
The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective. [PMID:26968346]	["Martini-Stoica H", "Xu Y", "Ballabio A	Trends in neurosciences	2016	0
The Lysosome as a Regulatory Hub. [PMID:27501449]	["Perera R", "Zoncu R"]	Annual review of cell and deve	2016	0