Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MITOCHONDRIAL BIOGENESIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MITOCHONDRIAL BIOGENESIS |
| Linked Hypotheses | 5 hypotheses |
Knowledge base pages for this entity
graph TD
MITOCHONDRIAL_BIOGENESIS["MITOCHONDRIAL BIOGENESIS"]
MITOCHONDRIAL_BIOGENESIS -->|"involved_in"| Mitochondrial_Bioenergetics["Mitochondrial Bioenergetics"]
MITOCHONDRIAL_BIOGENESIS -->|"treats"| Molybdenum_Cofactor_Deficiency["Molybdenum Cofactor Deficiency"]
MITOCHONDRIAL_BIOGENESIS -->|"mediates"| Mitochondrial_Pool_Maintenance["Mitochondrial Pool Maintenance"]
MITOCHONDRIAL_BIOGENESIS -.protects against.-> Mitochondrial_Dysfunction["Mitochondrial Dysfunction"]
MITOCHONDRIAL_BIOGENESIS -.protects against.-> Parkinson_s_Disease["Parkinson's Disease"]
MITOCHONDRIAL_BIOGENESIS -.protects against.-> Neurodegeneration["Neurodegeneration"]
PGC1A["PGC1A"] -->|"regulates"| MITOCHONDRIAL_BIOGENESIS
PGC1_["PGC1Alpha"] -->|"regulates"| MITOCHONDRIAL_BIOGENESIS
AMPK["AMPK"] -->|"activates"| MITOCHONDRIAL_BIOGENESIS
PGC_1_["PGC-1alpha"] -->|"promotes"| MITOCHONDRIAL_BIOGENESIS
PPARGC1A["PPARGC1A"] -->|"regulates"| MITOCHONDRIAL_BIOGENESIS
AMPK_PGC_1__signaling["AMPK/PGC-1alpha signaling"] -->|"activates"| MITOCHONDRIAL_BIOGENESIS| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegenerative Diseases | therapeutic_target | disease | 0.90 |
| Mitochondrial Bioenergetics | involved_in | process | 0.88 |
| Mitochondrial Bioenergetics | regulates | process | 0.85 |
| Molybdenum Cofactor Deficiency | treats | disease | 0.85 |
| Molybdenum Cofactor Deficiency | involved_in | disease | 0.85 |
| Mitochondrial bioenergetics | promotes | process | 0.85 |
| neurite injury | protects_against | phenotype | 0.85 |
| senescence | suppresses | phenotype | 0.85 |
| Mitochondrial Pool Maintenance | mediates | phenotype | 0.80 |
| molybdenum cofactor deficiency | disrupted_in | disease | 0.80 |
| Parkinson's Disease | protects_against | disease | 0.80 |
| Neurodegeneration | protects_against | disease | 0.80 |
| neurodegenerative disorders | protects_against | disease | 0.70 |
| mitochondrial mass | regulates | process | 0.70 |
| ageing | associated_with | disease | 0.70 |
| metabolic diseases | associated_with | disease | 0.70 |
| neurodegeneration | associated_with | disease | 0.70 |
| mitochondrial integrity | activates | process | 0.70 |
| mitochondrial function | regulates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PGC1Α | regulates | entity | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neur | 0.435 | translational neuroscience | Which metabolic biomarkers can distingui |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Alterations in mRNA level of proteins related to redox state and mitochondria in [PMID:39529534] | Żulińska S, Wencel PL, Czubowicz K, Stro | Folia Neuropathol | 2024 | 0 |
| 2,2',4,4'-Tetrabromodiphenyl ether disrupts spermatogenesis in mice by interferi [PMID:35238255] | Huang S, Xia J, Zhang X, Zhou T, Wang J | Toxicol Ind Health | 2022 | 0 |
| Glucagon regulates hepatic mitochondrial function and biogenesis through FOXO1. [PMID:31026811] | Yang W, Yan H, Pan Q, Shen JZ, Zhou F et | J Endocrinol | 2019 | 0 |