concept

MT-CO2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MT-CO2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

0Hypotheses

0Analyses

28Outgoing

19Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	MT-CO2
Key Genes/Proteins	PGC1α, MT-ND4L, APOPTOSIS, OXIDATIVE STRESS, MST1, AKT
Related Diseases	Alzheimer, Ms
Related Pathways	Akt, Mitochondrial Function, Apoptosis, Immune Response, Oxidative Stress

Wiki Pages (10)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MT_CO2["MT-CO2"]
    MT_CO2 -->|"regulates"| Alzheimer["Alzheimer"]
    MT_CO2 -->|"regulates"| Ms["Ms"]
    MT_CO2 -->|"regulates"| MT_ND4L["MT-ND4L"]
    MT_CO2 -->|"regulates"| APOPTOSIS["APOPTOSIS"]
    MT_CO2 -->|"regulates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    MT_CO2 -->|"regulates"| MST1["MST1"]
    MT_CO2 -->|"regulates"| Akt["Akt"]
    MT_CO2 -->|"regulates"| Mitochondrial_Function["Mitochondrial Function"]
    PGC1_["PGC1alpha"] -->|"regulates"| MT_CO2
    MT_ATP6["MT-ATP6"] -->|"regulates"| MT_CO2
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"regulates"| MT_CO2
    PI3K["PI3K"] -->|"regulates"| MT_CO2
    HIPPO["HIPPO"] -->|"regulates"| MT_CO2
    AKT["AKT"] -->|"regulates"| MT_CO2
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"regulates"| MT_CO2
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"regulates"| MT_CO2

Outgoing (28)

Target	Relation	Type	Str
Alzheimer	regulates	disease	0.65
Ms	regulates	disease	0.65
MT-ND4L	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
MST1	regulates	gene	0.60
Akt	regulates	pathway	0.60
Mitochondrial Function	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
Oxidative Stress	regulates	pathway	0.60
Pi3K	regulates	pathway	0.60
AKT	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
DNA	regulates	gene	0.60
ATP	regulates	gene	0.60
Hippo Pathway	regulates	pathway	0.60
HIPPO	regulates	gene	0.60
Neuron	regulates	cell_type	0.60
MT-ATP6	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
GENES	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
PI3K	regulates	gene	0.60
Actin	regulates	protein	0.60
Hippocampus	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (19)

Source	Relation	Type	Str
PGC1α	regulates	protein	0.70
MT-ATP6	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
PI3K	regulates	gene	0.60
HIPPO	regulates	gene	0.60
AKT	regulates	gene	0.60
MITOCHONDRIAL DNA	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
MT-ND4L	regulates	gene	0.60
ROS	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
MST1	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
GENES	regulates	gene	0.60
AND	regulates	gene	0.60
ATP	regulates	gene	0.60
DNA	regulates	gene	0.60
RNA	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MT-CO2

Understanding Entity Pages

Wiki Pages (10)

COX20 Gene - Cytochrome c Oxidase Assembly Factor

surf1

Mitochondrial DNA Mutations in Neurodegeneration

COA8 Gene - Cytochrome c Oxidase Assembly Factor 8

IARS2 — Isoleucyl-tRNA Synthetase 2, Mitochondrial

Selective Neuronal Vulnerability in Corticobasal Syndrome

Leigh Syndrome

Mitochondrial Complex IV (Cytochrome c Oxidase)