Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PHA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| iPSC-NPC effects on astrocytes in vitro ICH model | exploratory | intracerebral hemorrhage | 0.900 | 0.00 | in vitro ICH cell culture mode | completed | N/A |
| CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co | clinical | Alzheimer's Disease | 0.900 | 0.50 | aortic endothelial cells | proposed | $6,550,000 |
| Autophagy receptor identification for stress granule elimination | exploratory | neurodegenerative diseases | 0.900 | 0.00 | cultured cells under arsenite | proposed | N/A |
| Tau depletion effects on neuronal development in primary cultures | exploratory | 0.900 | 0.00 | primary rodent neuronal cultur | proposed | N/A | |
| Differential GWAS of schizophrenia vs PTSD | exploratory | schizophrenia, post-traumatic | 0.900 | 0.00 | human patients - European ance | proposed | N/A |
| Tau depletion effects on neuronal development in primary cultures | exploratory | 0.900 | 0.00 | primary rodent neuronal cultur | proposed | N/A | |
| Creation and validation of 3xAD-ChAT-Cre mouse model | validation | Alzheimer's disease | 0.900 | 0.00 | 3xAD-ChAT-Cre transgenic mice | proposed | N/A |
| AMPK knockdown validation experiment | exploratory | intracerebral hemorrhage | 0.880 | 0.00 | astrocyte cell culture | proposed | N/A |
| P2RY12-MTOR pathway interaction in VSMCs | exploratory | atherosclerosis | 0.850 | 0.00 | cultured VSMCs | proposed | N/A |
| iPSC-NPC transplantation in ICH animal model | validation | intracerebral hemorrhage | 0.850 | 0.00 | animal ICH model | proposed | N/A |
| GTEx brain tissue expression analysis of MAPT/CRHR1 locus | exploratory | schizophrenia, post-traumatic | 0.850 | 0.00 | human brain tissue samples fro | proposed | N/A |
| Microtubule domain analysis in adult axons | exploratory | 0.800 | 0.00 | adult rodent axons | proposed | N/A | |
| Tau depletion effects on microtubule domains in adult axons | exploratory | 0.800 | 0.00 | adult rodent neurons | proposed | N/A | |
| Sequential DFO + Sulforaphane Prevents Iron-Ferroptosis Cascade in Rat | in_vivo | post-cardiac-arrest neurodegen | 0.768 | 0.72 | Sprague-Dawley rat asphyxial c | abandoned | $48,000 |
| Closed-loop tFUS Enhances Glymphatic Clearance and Restores CA1 PV Int | in_vivo | Alzheimer's disease | 0.765 | 0.55 | APP/PS1 mice 8-11 months (n=10 | abandoned | $125,000 |
| s:** - Test tau spreading in AQP4 knockout vs wild-type mice with PSP/ | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $260,000 |
| Circadian-Vascular-Metabolic Syndrome (CVMS) Intervention Trial | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,900,000 |
| DLB Cognitive Fluctuation Mechanism Experiment | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Glymphatic-Circadian Axis Enhancement Therapy for Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Non-Motor Symptom Progression in Parkinson's Disease — Mechanisms and | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake [PMID:40439868] | Zheng Z, Xue F, Wang H, Gu Q, Hu R, Li X | Pharmacol Rep | 2025 | 1 |
| Genetic determinants of daytime napping and effects on cardiometabolic health. [PMID:33568662] | Dashti HS, Daghlas I, Lane JM, Huang Y, | Nat Commun | 2021 | 1 |
| Hypocretin/Orexin Receptor Pharmacology and Sleep Phases. [PMID:34052813] | Sun Y, Tisdale RK, Kilduff TS | Front Neurol Neurosci | 2021 | 1 |
| Sleep drives metabolite clearance from the adult brain. [PMID:24136970] | Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th | Science | 2013 | 1 |
| Replating Induces mTOR-Dependent Rescue of Protein Synthesis in Charcot-Marie-To [PMID:41876253] | Koenig J, McGuire A, Homedan Y, Alberhas | eNeuro | 2026 | 0 |
| S-equol promotes ferroptosis in triple negative breast cancer by coordinating NC [PMID:41925800] | Ni F, Huang Z, Cui Y, Huang P, Xue Z, Hu | Molecular and cellular biochem | 2026 | 0 |
| Metabolic dysregulation reshapes the immune landscape: The gut microbiota-mTOR a [PMID:41445190] | Li J, Li J, Chen K | Mol Ther | 2026 | 0 |
| Senecavirus a VP2 protein orchestrates PRDX1 degradation through dual autophagy [PMID:41479169] | Li Z, Yang X, Mao J, Zeng P, Qi Y et al. | Autophagy | 2026 | 0 |
| Inhibition of mTOR Enhances the Efficacy of Proteasome-Dependent Targeted Protei [PMID:41529091] | Liu Y, Sun Y, Song TY, Ni SY, Pu YS et a | Cancer Res | 2026 | 0 |
| Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180] | Yang FG, Yang H, Han SW, Wang JT, Gao W | Ageing Res Rev | 2026 | 0 |
| mTOR signaling pathway in primary Sjögren's syndrome: Pathogenesis and potential [PMID:41789635] | Huo R, Yang Y, Wei C, Yang Y, Meng D et | Int J Mol Med | 2026 | 0 |
| Microcystin-LR-induced phosphorylation imbalance and organelle stress: An integr [PMID:41846138] | Teng Z, Shahzad A, Xu Z, Xia J, Zhang J | J Hazard Mater | 2026 | 0 |
| Copper deficiency impairs oligodendrocyte maturation and social behavior via mit [PMID:41920999] | Usui N, Doi M, Berto S, Matsuoka K, Ishi | Sci Adv | 2026 | 0 |
| Crosstalk between inflammation and autophagy in CeD organoids. [PMID:41933042] | Bellomo C, Furone F, Auricchio R, D'Anie | Sci Rep | 2026 | 0 |
| Targeting the AKT/mTOR axis: pectolinarigenin induces autophagy and apoptosis in [PMID:41924135] | Fang Y, Bai J, Bo S, Cui X, Song H, Guo | Frontiers in pharmacology | 2026 | 0 |
| Targeting the GSK-3β/mTOR axis: a novel pharmacological strategy for preeclampsi [PMID:41922823] | Alshaikh ABA, Al-Kuraishy HM, Abdelaziz | Naunyn-Schmiedeberg's archives | 2026 | 0 |
| Platelet proteomic signatures of amyloid β-positive mild cognitive impairment an [PMID:41904574] | Cho YE, Kim A, Lee HM, Oh JW, Son SJ, Ro | Molecular brain | 2026 | 0 |
| Mapping the Brain's Glymphatic System. [PMID:41751308] | Voumvourakis K, Thomaidis NS, Tsiodras S | Biomedicines | 2026 | 0 |
| Targeting of the PI3K/AKT/mTOR signaling pathway in the neurovascular interface [PMID:41865874] | Alameen AAM, Al-Kuraishy HM, Al-Gareeb A | Microvascular research | 2026 | 0 |
| Neuroinflammation, Autophagy, and Neurodegeneration: Mechanisms and Therapeutic [PMID:41918200] | ["Khanal P", "Balmik A"] | CNS & neurological disorders d | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PHA in their description or question text
Score: 0.865 · neuroscience · 2026-04-07
## Mechanistic Overview Glymphatic-Mediated Tau Clearance Dysfunction starts from the claim that modulating MAPT within
Score: 0.838 · neurodegeneration · 2026-04-17
## Mechanistic Overview Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Prevents the Self-A
Score: 0.831 · protein-biochemistry · 2026-04-28
**Molecular Mechanism and Rationale** The J-protein co-chaperone system functions as a critical autophagy adapter mecha
Score: 0.827 · alzheimers · 2026-04-16
## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via glymph
Score: 0.826 · alzheimers · 2026-04-28
Auditory 40 Hz entrainment applied during NREM sleep consolidates temporal coupling between hippocampal theta oscillatio
Score: 0.824 · neurodegeneration · 2026-04-17
## Mechanistic Overview SIRT1 Activation Couples Mitochondrial Biogenesis to Ferroptosis Suppression via PGC1alpha-Depen
Score: 0.822 · neurodegeneration · 2026-04-05
## Mechanistic Overview Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-Synuclein Aggregates Drives Non-Cell-
Score: 0.820 · neurodegeneration · 2026-04-13
## Mechanistic Overview HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liquid Phase Separation start
Score: 0.820 · neurodegeneration · 2026-04-28
Impaired autophagic flux and lysosomal degradation capacity represents a convergent failure point across AD, PD, ALS, an
Score: 0.816 · multi · 2026-04-28
Shared mechanism across ALS, FTD: C9ORF72 repeat expansion creates toxic RNA/dipeptide stress while also weakening vesic
Score: 0.808 · neuroscience · 2026-04-28
Thalamic ventrobasal nucleus GluN2B-mediated burst firing entrains cortical slow-wave oscillations (0.5-1 Hz) during NRE
Score: 0.801 · neuroimmunology · 2026-04-15
## Mechanistic Overview CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Window Identification starts from the cl
Score: 0.796 · multi · 2026-04-28
Shared mechanism across PD, AD, ALS: Mitochondrial damage normally recruits PINK1/Parkin quality control; failure of thi
Score: 0.787 · neurodegeneration · 2026-04-16
## Mechanistic Overview VCP-Mediated Autophagy Enhancement starts from the claim that modulating VCP within the disease
Score: 0.784 · alzheimers · 2026-04-05
## Mechanistic Overview Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activate AMPK-autophag