Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PI3K-AKT SIGNALING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PI3K-AKT SIGNALING PATHWAY |
Knowledge base pages for this entity
graph TD
PI3K_AKT_SIGNALING_PATHWAY["PI3K-AKT SIGNALING PATHWAY"]
PI3K_AKT_SIGNALING_PATHWAY -->|"upstream_of"| platelet_activation["platelet activation"]
PI3K_AKT_SIGNALING_PATHWAY -->|"promotes"| lipid_deposition["lipid deposition"]
PI3K_AKT_SIGNALING_PATHWAY -->|"promotes"| inflammation["inflammation"]
PI3K_AKT_SIGNALING_PATHWAY -->|"regulates"| solar_dermatitis["solar dermatitis"]
PI3K_AKT_SIGNALING_PATHWAY -->|"modulates"| Neuronal_Apoptosis["Neuronal Apoptosis"]
PI3K_AKT_SIGNALING_PATHWAY -->|"promotes"| atherosclerosis["atherosclerosis"]
PI3K_AKT_SIGNALING_PATHWAY -->|"regulates"| TNF__["TNF-alpha"]
Fusobacterium_nucleatum["Fusobacterium nucleatum"] -->|"activates"| PI3K_AKT_SIGNALING_PATHWAY
AKT["AKT"] -->|"downstream_of"| PI3K_AKT_SIGNALING_PATHWAY
Gbp_protein["Gbp protein"] -->|"activates"| PI3K_AKT_SIGNALING_PATHWAY
Andrographis_paniculata["Andrographis paniculata"] -->|"modulates"| PI3K_AKT_SIGNALING_PATHWAY
Yiqi_Tongluo_Granule["Yiqi Tongluo Granule"] -->|"activates"| PI3K_AKT_SIGNALING_PATHWAY
QHZYF["QHZYF"] -->|"regulates"| PI3K_AKT_SIGNALING_PATHWAY
DOTP["DOTP"] -->|"modulates"| PI3K_AKT_SIGNALING_PATHWAY| Target | Relation | Type | Str |
|---|---|---|---|
| platelet activation | upstream_of | process | 0.90 |
| lipid deposition | promotes | process | 0.90 |
| solar dermatitis | associated_with | disease | 0.90 |
| inflammation | promotes | process | 0.90 |
| solar dermatitis | regulates | disease | 0.88 |
| inflammation | regulates | process | 0.87 |
| Neuronal Apoptosis | modulates | process | 0.85 |
| IL6 | regulates | protein | 0.85 |
| Pre-Regenerative Niche Formation | activates | process | 0.85 |
| atherosclerosis | promotes | disease | 0.85 |
| TNF-α | regulates | protein | 0.85 |
| inflammation | regulates | process | 0.82 |
| Cerebral Ischemia/Reperfusion Injury | protects_against | disease | 0.80 |
| coronary microembolism | promotes | disease | 0.80 |
| chronic spontaneous urticaria | associated_with | disease | 0.80 |
| ovarian cancer | associated_with | disease | 0.80 |
| IL-6 | upstream_of | protein | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Fusobacterium nucleatum | activates | pathogen | 0.95 |
| AKT | downstream_of | gene | 0.90 |
| Gbp protein | activates | protein | 0.88 |
| Andrographis paniculata | modulates | drug | 0.88 |
| Yiqi Tongluo Granule | activates | drug | 0.85 |
| QHZYF | regulates | drug | 0.85 |
| DOTP | modulates | drug | 0.85 |
| QHZYF | regulates | drug | 0.85 |
| MTOR | downstream_of | protein | 0.85 |
| UV exposure | activates | process | 0.82 |
| EGFR | upstream_of | protein | 0.80 |
| MYC | downstream_of | gene | 0.80 |
| DOTP | modulates | drug | 0.75 |
| TNF | upstream_of | protein | 0.75 |
| PFOA | modulates | drug | 0.75 |
| TNF-α | upstream_of | protein | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||