Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Ovarian Cancer: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | Mechanosensitive Ion Channels, AKT, PI3K, CANCER, MTOR, BRCA1, PTEN, ARID1A |
| Therapeutic Agents | PARP Inhibitors, Sy-1365, Parp Inhibitors, PARP inhibitor, HDAC inhibitors, Prmt Inhibitors |
| KG Connections | 354 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Ovarian_Cancer["<b>Ovarian Cancer</b>"]
Cancer{"Cancer"}
Ovarian_Cancer -->|"therapeutic_target"| Cancer
Autophagy["Autophagy"]
Ovarian_Cancer -.->|"inhibits"| Autophagy
Als{"Als"}
Ovarian_Cancer -->|"therapeutic_target"| Als
CANCER(["CANCER"])
CANCER -->|"therapeutic_target"| Ovarian_Cancer
Tumor{"Tumor"}
Tumor -->|"therapeutic_target"| Ovarian_Cancer
style Ovarian_Cancer fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | therapeutic_target | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Late-Stage Diagnosis | associated_with | phenotype | 0.95 |
| Autophagy | inhibits | pathway | 0.90 |
| Als | therapeutic_target | disease | 0.85 |
| Cancer | associated_with | disease | 0.75 |
| Cancer | biomarker_for | disease | 0.75 |
| Tumor Microenvironment | therapeutic_target | pathway | 0.70 |
| Autophagy | activates | pathway | 0.70 |
| Autophagy | regulates | pathway | 0.70 |
| Oxidative Stress | therapeutic_target | pathway | 0.70 |
| Pi3K/Akt | treats | pathway | 0.70 |
| Apoptosis | treats | pathway | 0.70 |
| Invasion | treats | pathway | 0.70 |
| Mtor | activates | pathway | 0.70 |
| Wnt | associated_with | pathway | 0.70 |
| Oxidative Phosphorylation | activates | pathway | 0.70 |
| Apoptosis | activates | pathway | 0.70 |
| Invasion | activates | pathway | 0.70 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Breast Cancer | activates | disease | 0.65 |
| Checkpoint Inhibitor | inhibits | pathway | 0.60 |
| Angiogenesis | therapeutic_target | pathway | 0.60 |
| Immune Checkpoint | inhibits | pathway | 0.60 |
| Mtor | implicated_in | pathway | 0.60 |
| Pi3K/Akt | implicated_in | pathway | 0.60 |
| Chemoresistance | therapeutic_target | pathway | 0.60 |
| Mtor | regulates | pathway | 0.60 |
| Cell Cycle | regulates | pathway | 0.60 |
| Dna Repair | regulates | pathway | 0.60 |
| Pi3K/Akt | therapeutic_target | pathway | 0.60 |
| Dna Repair | therapeutic_target | pathway | 0.60 |
| Mtor | therapeutic_target | pathway | 0.60 |
| Microrna | therapeutic_target | pathway | 0.60 |
| Homologous Recombination | therapeutic_target | pathway | 0.60 |
| Mitophagy | activates | pathway | 0.60 |
| Chemoresistance | associated_with | pathway | 0.60 |
| Oxidative Stress | associated_with | pathway | 0.60 |
| Senescence | activates | pathway | 0.60 |
| Cholesterol | regulates | pathway | 0.60 |
| Lipid Metabolism | therapeutic_target | pathway | 0.60 |
| Ferroptosis | activates | pathway | 0.60 |
| Oxidative Stress | activates | pathway | 0.60 |
| Drug Resistance | therapeutic_target | pathway | 0.60 |
| Metastasis | regulates | pathway | 0.60 |
| Chemoresistance | regulates | pathway | 0.60 |
| Tumor Microenvironment | activates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CANCER | therapeutic_target | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| CANCER | activates | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| AUTOPHAGY | inhibits | gene | 0.95 |
| Tumor | activates | disease | 0.95 |
| Mechanosensitive Ion Channels | associated_with | protein | 0.90 |
| Mechanosensitive Ion Channel | associated_with | protein | 0.90 |
| PARP1 | associated_with | protein | 0.90 |
| MECHANOSENSITIVE ION CHANNEL | associated_with | protein | 0.90 |
| Endometriosis | risk_factor_for | disease | 0.90 |
| Mechanosensitive Ion Channel | involved_in | mechanism | 0.90 |
| PARP inhibitor resistance | associated_with | phenotype | 0.90 |
| PRMT5 | therapeutic_target | gene | 0.90 |
| DOT1L | associated_with | gene | 0.90 |
| PIEZO1 | biomarker_for | gene | 0.85 |
| PARP Inhibitors | treats | drug | 0.85 |
| PTEN | associated_with | gene | 0.85 |
| Cancer | inhibits | disease | 0.85 |
| CANCER | biomarker_for | gene | 0.85 |
| GENES | associated_with | gene | 0.85 |
| TRPV1 | biomarker_for | gene | 0.85 |
| PIEZO2 | biomarker_for | gene | 0.85 |
| PARP1 Trapping | involved_in | process | 0.85 |
| Parp Inhibitors | treats | drug | 0.85 |
| PIEZO2 | associated_with | gene | 0.85 |
| Focal Adhesion | associated_with | pathway | 0.85 |
| Wnt Signaling Pathway | contributes_to | pathway | 0.85 |
| Hippo Signaling Pathway | contributes_to | pathway | 0.85 |
| DOT1L | upregulates | gene | 0.85 |
| PARP inhibitor | treats | drug | 0.85 |
| XPR1 | therapeutic_target | gene | 0.85 |
| SPINT1 | therapeutic_target | gene | 0.85 |
| NFE2L3 | therapeutic_target | gene | 0.85 |
| FGFRL1 | therapeutic_target | gene | 0.85 |
| PRMT1 | therapeutic_target | gene | 0.85 |
| XPR1 | associated_with | gene | 0.85 |
| SPINT1 | associated_with | gene | 0.85 |
| NFE2L3 | associated_with | gene | 0.85 |
| GRAMD1B | associated_with | gene | 0.85 |
| Prmt Inhibitors | treats | drug | 0.85 |
| Extracellular Matrix-Receptor Interaction | involved_in | pathway | 0.82 |
| PIEZO1 | associated_with | gene | 0.80 |
| SCN5A | associated_with | gene | 0.80 |
| KCNQ1 | associated_with | gene | 0.80 |
| SCN5A | biomarker_for | gene | 0.80 |
| TRPV4 | associated_with | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||