concept

PRKAA1/2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRKAA1/2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

11Outgoing

6Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	PRKAA1/2
Key Genes/Proteins	MTOR, ULK1, AUTOPHAGY, SIRT1, FOXO, AND
Related Diseases	ALS, Als
Related Pathways	Mtor

Pathway Diagram

graph TD
    PRKAA1_2["PRKAA1/2"]
    PRKAA1_2 -->|"activates"| Autophagy["Autophagy"]
    PRKAA1_2 -->|"modulates"| MTOR["MTOR"]
    PRKAA1_2 -->|"activates"| ALS["ALS"]
    PRKAA1_2 -->|"activates"| Als["Als"]
    PRKAA1_2 -->|"activates"| ULK1["ULK1"]
    PRKAA1_2 -->|"activates"| Mtor["Mtor"]
    PRKAA1_2 -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
    PRKAA1_2 -->|"activates"| SIRT1["SIRT1"]
    Metformin["Metformin"] -->|"activates"| PRKAA1_2
    PRKAA1["PRKAA1"] -->|"activates"| PRKAA1_2
    AUTOPHAGY -->|"activates"| PRKAA1_2
    AND["AND"] -->|"activates"| PRKAA1_2
    SIRT1 -->|"activates"| PRKAA1_2
    MTOR -->|"activates"| PRKAA1_2

Outgoing (11)

Target	Relation	Type	Str
Autophagy	activates	process	0.85
MTOR	modulates	gene	0.80
ALS	activates	disease	0.65
Als	activates	disease	0.65
ULK1	activates	gene	0.60
Mtor	activates	pathway	0.60
AUTOPHAGY	activates	gene	0.60
SIRT1	activates	gene	0.60
FOXO	activates	gene	0.60
AND	activates	gene	0.60
Hepatocyte	activates	cell_type	0.60

Incoming (6)

Source	Relation	Type	Str
Metformin	activates	drug	0.90
PRKAA1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
AND	activates	gene	0.60
SIRT1	activates	gene	0.60
MTOR	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found