Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Hepatocyte: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | HEPATOCYTE |
| Associated Diseases | Als, Ischemia, Cancer, Fibrosis, Pyroptosis, Ferroptosis |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
FOXO1["FOXO1"] -->|"expressed in"| Hepatocyte["Hepatocyte"]
style FOXO1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
E2F3["E2F3"] -->|"regulates"| Hepatocyte["Hepatocyte"]
style E2F3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
E2F1["E2F1"] -->|"regulates"| Hepatocyte["Hepatocyte"]
style E2F1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
E2F7["E2F7"] -->|"regulates"| Hepatocyte["Hepatocyte"]
style E2F7 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
E2F8["E2F8"] -->|"regulates"| Hepatocyte["Hepatocyte"]
style E2F8 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
style Hepatocyte fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| TGFB1 | expressed_in | gene | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FOXO1 | expressed_in | gene | 0.90 |
| E2F3 | regulates | gene | 0.60 |
| E2F1 | regulates | gene | 0.60 |
| E2F7 | regulates | gene | 0.60 |
| E2F8 | regulates | gene | 0.60 |
| E2F2 | regulates | gene | 0.60 |
| DNA | regulates | gene | 0.60 |
| PPARG | activates | gene | 0.60 |
| PPARGC1A | activates | gene | 0.60 |
| MITOCHONDRIA | activates | gene | 0.60 |
| SREBF1 | activates | gene | 0.60 |
| LAMP1 | activates | gene | 0.60 |
| EIF4EBP1 | activates | gene | 0.60 |
| CTSD | activates | gene | 0.60 |
| NADH | activates | gene | 0.60 |
| ACTB | activates | gene | 0.60 |
| RAS | activates | gene | 0.60 |
| CPT1A | activates | gene | 0.60 |
| RAB7A | activates | gene | 0.60 |
| PPARA | activates | gene | 0.60 |
| CAT | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| HFE | interacts_with | gene | 0.60 |
| TFR1 | regulates | gene | 0.60 |
| JUN | regulates | gene | 0.60 |
| MITOCHONDRIA | regulates | gene | 0.60 |
| FERROPORTIN | transports | gene | 0.60 |
| DMT1 | transports | gene | 0.60 |
| TFR1 | transports | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| FOXO1 | activates | gene | 0.60 |
| CCL4 | activates | gene | 0.60 |
| ALOX12 | activates | gene | 0.60 |
| JUN | inhibits | gene | 0.60 |
| CPT1A | inhibits | gene | 0.60 |
| ALOX15 | inhibits | gene | 0.60 |
| MLKL | inhibits | gene | 0.60 |
| HMGCR | inhibits | gene | 0.60 |
| GSDMD | inhibits | gene | 0.60 |
| PPAR | inhibits | gene | 0.60 |
| FERROPTOSIS | inhibits | gene | 0.60 |
| ACSL4 | inhibits | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
| FASN | inhibits | gene | 0.60 |
| SCD1 | inhibits | gene | 0.60 |
| ROS | inhibits | gene | 0.60 |
| PYROPTOSIS | inhibits | gene | 0.60 |
| CYTOKINES | contributes_to | gene | 0.60 |
| ATP | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||