Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PSMB7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | PSMB7 |
| Chromosome | 9q34.3 |
| Protein Type | Protease, Hydrolase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Ubiquitous (all tissues) |
| Molecular Weight | 30.2 kDa |
| UniProt ID | P99416 |
| NCBI Gene ID | 5719 |
| Ensembl ID | ENSG00000136930 |
| OMIM | 176843 |
| GeneCards | PSMB7 |
| Human Protein Atlas | PSMB7 |
| Symbol [@mcnaught2001] PSMB7 [@kotrschmar2019] [@cheroni2009] [@jana2001] Full Name [@myeku2016] Proteasome Subunit Beta Type-7 Also Known As | Proteasome subunit Z, MC14 |
| Protein Class | Protease, Hydrolase |
| Interactions | APP, PSMA5, SLC1A2 |
| KG Connections | 18 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PSMB7["<b>PSMB7</b>"]
Alzheimer{"Alzheimer"}
PSMB7 -->|"expressed in"| Alzheimer
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
PSMB7 -->|"expressed in"| ALZHEIMER_S_DISEASE
P53["P53"]
PSMB7 -->|"expressed in"| P53
APP["APP"]
PSMB7 -->|"inhibits"| APP
PSMA5["PSMA5"]
PSMB7 -->|"inhibits"| PSMA5
Neurogenesis(["Neurogenesis"])
PSMB7 -->|"expressed in"| Neurogenesis
neurodegeneration["neurodegeneration"]
PSMB7 -->|"implicated in"| neurodegeneration
style PSMB7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | expressed_in | disease | 0.65 |
| Neurodegeneration | interacts_with | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| Dementia | interacts_with | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Tauopathy | interacts_with | disease | 0.65 |
| APP | inhibits | gene | 0.60 |
| PSMA5 | inhibits | gene | 0.60 |
| SLC1A2 | interacts_with | gene | 0.60 |
| PSP | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | expressed_in | gene | 0.60 |
| P53 | expressed_in | gene | 0.60 |
| Neurogenesis | expressed_in | pathway | 0.60 |
| Proteasome | associated_with | pathway | 0.60 |
| Neurogenesis | interacts_with | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||