Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB11A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Page for RAB11A - small GTPase regulating synaptic vesicle recycling, endosomal trafficking in neurodegenerative diseases
| Gene Symbol | RAB11A |
| Full Name | Ras-Related Protein Rab-11A |
| Aliases | Page for RAB11A |
| Function | RAB11A functions in the recycling endosome compartment |
| Molecular Weight | 24 kDa |
| Amino Acids | 216 aa |
| UniProt ID | RAB11A |
| Ensembl ID | ENSG00000103740 |
| GeneCards | RAB11A |
| Human Protein Atlas | RAB11A |
| Receptor recycling | Controls recycling of AMPA, NMDA, and GABA receptors to the plasma membrane<sup>[1]</sup> |
| Synaptic plasticity | Essential for activity-dependent synaptic modification |
| Neurotrophin trafficking | Regulates BDNF/TrkB receptor recycling |
| Membrane protein turnover | Participates in cargo sorting in the recycling pathway |
| Cell division | Regulates cell polarity and cytokinesis (non-neuronal) |
| Associated Diseases | neurodegeneration |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RAB11A["<b>RAB11A</b>"]
Ms{"Ms"}
RAB11A -->|"regulates"| Ms
Als{"Als"}
RAB11A -->|"regulates"| Als
Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
RAB11A -->|"regulates"| Amyotrophic_Lateral_Sclerosis
DNAJC5(["DNAJC5"])
RAB11A -->|"regulates"| DNAJC5
ATG7(["ATG7"])
RAB11A -->|"regulates"| ATG7
VAMP7(["VAMP7"])
RAB11A -->|"regulates"| VAMP7
AMYOTROPHIC_LATERAL_SCLEROSIS(["AMYOTROPHIC LATERAL SCLEROSIS"])
AMYOTROPHIC_LATERAL_SCLEROSIS -->|"regulates"| RAB11A
RAB8A(["RAB8A"])
RAB8A -->|"regulates"| RAB11A
ALS(["ALS"])
ALS -->|"regulates"| RAB11A
style RAB11A fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Source | Relation | Type | Str |
|---|---|---|---|
| RAB8A | regulates | gene | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | regulates | gene | 0.60 |
| ALS | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||