VAMP7

Understanding Entity Pages

This page aggregates everything SciDEX knows about VAMP7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

VAMP7 (Vesicle-Associated Membrane Protein 7, also TI-VAMP) is a longin domain-containing SNARE protein essential for synaptic vesicle trafficking, lysosomal fusion, and autophagy. Implicated in Alzheimer's disease, Parkinson's disease, and Hermansky-Pudlak syndrome.

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graph TD
    VAMP7["<b>VAMP7</b>"]
    Ms{"Ms"}
    VAMP7 -->|"associated with"| Ms
    Als{"Als"}
    VAMP7 -->|"associated with"| Als
    ALS{"ALS"}
    VAMP7 -->|"associated with"| ALS
    STX17["STX17"]
    VAMP7 -->|"associated with"| STX17
    RAB7A["RAB7A"]
    VAMP7 -->|"associated with"| RAB7A
    SNAP29["SNAP29"]
    VAMP7 -->|"associated with"| SNAP29
    GABARAPL1["GABARAPL1"]
    VAMP7 -->|"associated with"| GABARAPL1
    MAP1LC3B["MAP1LC3B"]
    VAMP7 -->|"associated with"| MAP1LC3B
    RB1["RB1"]
    VAMP7 -->|"associated with"| RB1
    PRKN["PRKN"]
    VAMP7 -->|"associated with"| PRKN
    RB1CC1["RB1CC1"]
    VAMP7 -->|"associated with"| RB1CC1
    Lysosomal_Degradation(["Lysosomal Degradation"])
    VAMP7 -->|"associated with"| Lysosomal_Degradation
    GABARAP["GABARAP"]
    GABARAP -->|"associated with"| VAMP7
    VAMP8["VAMP8"]
    VAMP8 -->|"associated with"| VAMP7
    RTN3["RTN3"]
    RTN3 -->|"associated with"| VAMP7
    LAMP2["LAMP2"]
    LAMP2 -->|"associated with"| VAMP7
    DNM1L["DNM1L"]
    DNM1L -->|"associated with"| VAMP7
    ULK1["ULK1"]
    ULK1 -->|"associated with"| VAMP7
    LC3["LC3"]
    LC3 -->|"associated with"| VAMP7
    MTOR["MTOR"]
    MTOR -->|"associated with"| VAMP7
    RAB2A["RAB2A"]
    RAB2A -->|"associated with"| VAMP7
    MAP1LC3B -->|"associated with"| VAMP7
    PRKN -->|"associated with"| VAMP7
    RB1 -->|"associated with"| VAMP7
    style VAMP7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0