Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB8A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | RAB8A |
| Full Name | RAB8A, Member RAS Oncogene Family |
| Aliases | Ras-Related Protein |
| Chromosome | 19p13.2 |
| Function | RAB8A encodes a member of the Rab GTPase family, which are key regulators of intracellular vesicle trafficking |
| Molecular Weight | 24 kDa |
| Pathways | Cholesterol |
| UniProt ID | P61006 |
| NCBI Gene ID | 51528 |
| Ensembl ID | ENSG00000135569 |
| OMIM | 608030 |
| GeneCards | RAB8A |
| Human Protein Atlas | RAB8A |
| Strategy | Drug/Approach |
| Modulator | CID-1067700 (Rab inhibitor) |
| Associated Diseases | neurodegeneration |
| Interactions | NPC1, SMCR8, C9ORF72, SNAP23, STX4, ALS |
| KG Connections | 60 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RAB8A["<b>RAB8A</b>"]
Parkinson{"Parkinson"}
RAB8A -->|"inhibits"| Parkinson
Ms{"Ms"}
RAB8A -->|"inhibits"| Ms
Als{"Als"}
RAB8A -->|"therapeutic target"| Als
RAB8A -->|"interacts with"| Ms
NPC1["NPC1"]
RAB8A -->|"inhibits"| NPC1
Cholesterol(["Cholesterol"])
RAB8A -->|"regulates"| Cholesterol
CANX["CANX"]
RAB8A -->|"therapeutic target"| CANX
HSPA5["HSPA5"]
RAB8A -->|"therapeutic target"| HSPA5
neurodegeneration["neurodegeneration"]
RAB8A -->|"implicated in"| neurodegeneration
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"inhibits"| RAB8A
LRRK2["LRRK2"]
LRRK2 -->|"regulates"| RAB8A
RAB7A["RAB7A"]
RAB7A -->|"therapeutic target"| RAB8A
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
NEURODEGENERATIVE_DISEASES -->|"interacts with"| RAB8A
IGF2R["IGF2R"]
IGF2R -->|"therapeutic target"| RAB8A
CAPZB["CAPZB"]
CAPZB -->|"therapeutic target"| RAB8A
RAB5A["RAB5A"]
RAB5A -->|"therapeutic target"| RAB8A
HSPA1A["HSPA1A"]
HSPA1A -->|"therapeutic target"| RAB8A
style RAB8A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Autophagy | regulates | process | 0.85 |
| autophagy pathway | participates_in | pathway | 0.70 |
| Parkinson | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | regulates | disease | 0.65 |
| Ftd | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | inhibits | disease | 0.65 |
| Dementia | inhibits | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| NPC1 | inhibits | gene | 0.60 |
| CANX | therapeutic_target | gene | 0.60 |
| HSPA5 | therapeutic_target | gene | 0.60 |
| RAB11A | regulates | gene | 0.60 |
| DNAJC5 | regulates | gene | 0.60 |
| ATG7 | regulates | gene | 0.60 |
| VAMP7 | regulates | gene | 0.60 |
| UBIQUITIN | regulates | gene | 0.60 |
| RAB27A | regulates | gene | 0.60 |
| SMCR8 | inhibits | gene | 0.60 |
| C9ORF72 | inhibits | gene | 0.60 |
| LRRK2 | regulates | gene | 0.60 |
| NPC1 | regulates | gene | 0.60 |
| SNAP23 | inhibits | gene | 0.60 |
| STX4 | inhibits | gene | 0.60 |
| SNAP23 | activates | gene | 0.60 |
| STX4 | activates | gene | 0.60 |
| Cholesterol | regulates | pathway | 0.60 |
| ALS | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| ALS | inhibits | gene | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| DEMENTIA | inhibits | gene | 0.60 |
| App | inhibits | protein | 0.60 |
| Macrophage | expressed_in | cell_type | 0.55 |
| T Cell | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LRRK2 | phosphorylates | protein | 0.90 |
| C9Orf72-Smcr8 | interacts_with | protein | 0.90 |
| C9orf72-SMCR8 Complex | modulates | protein | 0.80 |
| LRRK2 | regulates | gene | 0.60 |
| RAB7A | therapeutic_target | gene | 0.60 |
| IGF2R | therapeutic_target | gene | 0.60 |
| CAPZB | therapeutic_target | gene | 0.60 |
| RAB5A | therapeutic_target | gene | 0.60 |
| HSPA1A | therapeutic_target | gene | 0.60 |
| SMCR8 | inhibits | gene | 0.60 |
| C9ORF72 | inhibits | gene | 0.60 |
| LRRK2 | activates | gene | 0.60 |
| PARKINSON'S DISEASE | inhibits | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | interacts_with | gene | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | regulates | gene | 0.60 |
| DEMENTIA | inhibits | gene | 0.60 |
| ALS | inhibits | gene | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.521
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||