Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RANPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Ran Gtpase Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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| Gene Symbol | RANPROTEIN |
| Full Name | RAN GTPase |
| Protein Family | Ras superfamily, Rab subfamily |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 24 kDa |
| Amino Acids | 216 amino acids |
| UniProt ID | P62834 |
| GeneCards | RANPROTEIN |
| Human Protein Atlas | RANPROTEIN |
| Nuclear localization signal | Although primarily nuclear, RAN contains motifs for nuclear import[@cook2007] |
| Importin-β shuttling | RAN-GTP regulates the binding and release of importin-β and importin-α, controlling protein import into the nucleus[@gorlich1996] |
| Nuclear-cytoplasmic gradient | The RAN-GTP gradient across the nuclear envelope is essential for directional transport |
| Protein and RNA export | RAN regulates the export of proteins, mRNA, and other cargo through the nuclear pore complex (NPC)[@tran2006] |
| CRM1/exportin pathway | RAN-GTP regulates the CRM1-mediated export pathway |
| Associated Diseases | Aging, Als, Amyotrophic Lateral Sclerosis, Ataxia, Dementia, frontotemporal dementia |
| Known Drugs/Compounds | metformin, rapamycin |
| Interactions | Actin, Akt, AKT, ALS, AMPK, AMYOTROPHIC LATERAL SCLEROSIS |
| KG Connections | 154 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RANPROTEIN["RANPROTEIN"]
neurodegeneration["neurodegeneration"]
RANPROTEIN -->|"implicated_in"| neurodegeneration
style RANPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RANPROTEIN in their description or question text
No additional research found