Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RASA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive information about RASA1, a RAS GTPase-activating protein involved in cell signaling, vascular development, and neurodegenerative processes.
| Gene Symbol | RASA1 |
| Full Name | RAS p120 GTPase Activating Protein |
| Chromosome | 5q14.1 |
| Protein Family | RAS GTPase-activating proteins |
| Function | is a critical regulator of RAS signaling pathways, functioning as a GTPase-activating protein (GAP) that accelerates the intrinsic GTP hydrolysis of RAS proteins. |
| Primary Expression | neurons and glial cells, particularly in the hippocampus and cortex - Heart and skeletal muscle: Moderate expression - Kidney and liver: Prese |
| Amino Acids | 1047 aa |
| Exons | 33 |
| Pathways | Cerebrovascular Development, MAPK signaling |
| UniProt ID | [P20156](https://www.uniprot.org/uniprot/P20156) |
| Ensembl ID | ENSG00000101577 |
| GeneCards | RASA1 |
| Human Protein Atlas | RASA1 |
| Vascular endothelium | High expression in endothelial cells lining blood vessels |
| Brain | Expressed in neurons and glial cells, particularly in the hippocampus and cortex |
| Associated Diseases | AD, ALI, ALS, AMI, Congenital Cerebrovascular Disease |
| Interactions | MAPK |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RASA1["<b>RASA1</b>"]
Ms{"Ms"}
RASA1 -->|"associated with"| Ms
Als{"Als"}
RASA1 -->|"associated with"| Als
ALS{"ALS"}
RASA1 -->|"causes"| ALS
EPHB4["EPHB4"]
RASA1 -->|"associated with"| EPHB4
Cerebrovascular(["Cerebrovascular"])
RASA1 -->|"associated with"| Cerebrovascular
AD{"AD"}
RASA1 -->|"implicated in"| AD
ALI{"ALI"}
RASA1 -->|"implicated in"| ALI
RASA1 -->|"implicated in"| Als
AMI{"AMI"}
RASA1 -->|"implicated in"| AMI
RASA1 -->|"implicated in"| Ms
RA{"RA"}
RASA1 -->|"implicated in"| RA
SS{"SS"}
RASA1 -->|"implicated in"| SS
EPHB4 -->|"associated with"| RASA1
AND["AND"]
AND -->|"associated with"| RASA1
style RASA1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| VEIN OF GALEN MALFORMATION | associated_with | entity | 0.90 |
| Cerebrovascular Development | involved_in | process | 0.90 |
| Vein Of Galen Malformation | associated_with | disease | 0.85 |
| Congenital Cerebrovascular Disease | associated_with | disease | 0.80 |
| Ms | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| ALS | causes | disease | 0.65 |
| EPHB4 | associated_with | gene | 0.60 |
| Cerebrovascular | associated_with | pathway | 0.60 |
| AND | associated_with | gene | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| ALS | associated_with | disease | 0.60 |
| AD | implicated_in | disease | 0.50 |
| ALI | implicated_in | disease | 0.50 |
| Als | implicated_in | disease | 0.50 |
| AMI | implicated_in | disease | 0.50 |
| Ms | implicated_in | disease | 0.50 |
| RA | implicated_in | disease | 0.50 |
| SS | implicated_in | disease | 0.50 |
| disease | implicated_in | disease | 0.50 |
| disease | associated_with | disease | 0.50 |
| Cerebrovascular | interacts_with | pathway | 0.50 |
| disease | causes | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||