concept

RA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

158Connections

30Hypotheses

30Analyses

0Outgoing

50Incoming

Summary

RA is a concept in neurodegeneration research. Key relationships include: implicated in, associated with. Connected to 158 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	RA
Summary	Page for RA Capital Management
Key Genes/Proteins	RBP, MAP1B, MAP2, MAP6, GLUT4, PPAR
Linked Hypotheses	291 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RA["RA"]
    MAP1B["MAP1B"] -->|"implicated in"| RA
    MAP2["MAP2"] -->|"implicated in"| RA
    MAP6["MAP6"] -->|"implicated in"| RA
    GLUT4["GLUT4"] -->|"implicated in"| RA
    PPAR["PPAR"] -->|"implicated in"| RA
    RAB7A["RAB7A"] -->|"implicated in"| RA
    LRP2["LRP2"] -->|"implicated in"| RA
    ACTB["ACTB"] -->|"implicated in"| RA
    CTSD["CTSD"] -->|"implicated in"| RA
    ATG["ATG"] -->|"implicated in"| RA

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (158)

Source	Relation	Type	Str
RBP	associated_with	protein	0.56
MAP1B	implicated_in	gene	0.50
MAP2	implicated_in	gene	0.50
MAP6	implicated_in	gene	0.50
GLUT4	implicated_in	gene	0.50
PPAR	implicated_in	gene	0.50
RAB7A	implicated_in	gene	0.50
LRP2	implicated_in	gene	0.50
ACTB	implicated_in	gene	0.50
CTSD	implicated_in	gene	0.50
ATG	implicated_in	gene	0.50
EGFR	implicated_in	gene	0.50
SREBF1	implicated_in	gene	0.50
NADH	implicated_in	gene	0.50
MTORC1	implicated_in	gene	0.50
PPARG	implicated_in	gene	0.50
RPS6KB1	implicated_in	gene	0.50
PPARA	implicated_in	gene	0.50
LAMP1	implicated_in	gene	0.50
RUBCN	implicated_in	gene	0.50
MTOR	implicated_in	gene	0.50
RAS	implicated_in	gene	0.50
RPS6	implicated_in	gene	0.50
PIK3C3	implicated_in	gene	0.50
ATP	implicated_in	gene	0.50
SQSTM1	implicated_in	gene	0.50
CAT	implicated_in	gene	0.50
ROS	implicated_in	gene	0.50
BACE1	implicated_in	gene	0.50
LIS1	implicated_in	gene	0.50
DCX	implicated_in	gene	0.50
CD2AP	implicated_in	gene	0.50
RELN	implicated_in	gene	0.50
APOE	implicated_in	gene	0.50
HCN1	implicated_in	gene	0.50
HCN4	implicated_in	gene	0.50
HCN2	implicated_in	gene	0.50
SLC16A2	implicated_in	gene	0.50
SLC16A1	implicated_in	gene	0.50
GSS	implicated_in	gene	0.50
CYP2E1	implicated_in	gene	0.50
IDH2	implicated_in	gene	0.50
IDH1	implicated_in	gene	0.50
VEGFA	implicated_in	gene	0.50
EEF1A1	implicated_in	gene	0.50
APOB	implicated_in	gene	0.50
MET	implicated_in	gene	0.50
MCL1	implicated_in	gene	0.50
SF3B1	implicated_in	gene	0.50
SMARCA4	implicated_in	gene	0.50

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE4-Specific Lipidation Enhancement Therapy	0.845	Alzheimer's disease	-
Closed-loop transcranial focused ultrasound to restore hippo	0.709	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II SST interneurons to block t	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
TREM2-Dependent Microglial Senescence Transition	0.692	neurodegeneration	Gene expression changes in aging mouse b

Closed-loop transcranial focused ultrasound with 40Hz gamma	0.689	Alzheimer's disease	Circuit-level neural dynamics in neurode
Gamma entrainment therapy to restore hippocampal-cortical sy	0.681	Alzheimer's disease	Circuit-level neural dynamics in neurode
CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind	0.674	neuroimmunology	What is the temporal sequence of TREM2 s
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.670	Alzheimer's disease	Circuit-level neural dynamics in neurode
Beta-frequency entrainment therapy targeting PV interneuron-	0.669	Alzheimer's disease	Circuit-level neural dynamics in neurode
Transcriptional Autophagy-Lysosome Coupling	0.665	neurodegeneration	Autophagy-lysosome pathway convergence a
Stathmin-2 Splice Switching to Prevent Axonal Degeneration A	0.664	neurodegeneration	RNA binding protein dysregulation across
STMN2 Restoration as a Prerequisite for Axon Growth After TD	0.658	neurodegeneration	What molecular mechanisms enable functio
Temporal SPP1 Inhibition During Critical Windows	0.650	neuroinflammation	What molecular mechanisms mediate SPP1-i
Selective Acid Sphingomyelinase Modulation Therapy	0.648	neurodegeneration	Lipid raft composition changes in synapt
Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone	0.645	neurodegeneration	What are the precise temporal dynamics o
Closed-loop transcranial alternating current stimulation to	0.639	Alzheimer's disease	Circuit-level neural dynamics in neurode
TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen	0.639	neurodegeneration	Gene expression changes in aging mouse b
SASP-Driven Microglial Metabolic Reprogramming in Synaptic P	0.638	neurodegeneration	Senolytic therapy for age-related neurod
TREM2-Dependent Microglial Phagocytosis Acts as a Strain Sel	0.636	neurodegeneration	What are the specific molecular determin
Closed-loop transcranial focused ultrasound to restore hippo	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microgl	0.632	neuroinflammation	How do oligodendrocytes initiate neuroin
CYP46A1 Overexpression Gene Therapy	0.631	neurodegeneration	Lipid raft composition changes in synapt
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode
Circadian Glymphatic Entrainment via Targeted Orexin Recepto	0.623	neurodegeneration	Perivascular spaces and glymphatic clear
CSF Biomarker-Guided ABCA7 Therapeutic Dosing	0.619	neurodegeneration	Why does the V1613M variant reduce amylo
Chromatin Remodeling-Mediated Nutrient Sensing Restoration	0.619	neurodegeneration	Epigenetic reprogramming in aging neuron
Integrated Biomarker Panel for Therapeutic Window Identifica	0.615	neurodegeneration	What are the precise temporal dynamics o
APOE-Dependent Autophagy Restoration	0.615	neurodegeneration	Mechanistic role of APOE in neurodegener

Mentioning Analyses (30)

Scientific analyses that reference this entity

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.596

What are the specific molecular determinants that govern tau strain selection du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.636

What are the cell-type-specific transcriptomic signatures of vulnerability in SE

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.576

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

drug delivery | 2026-04-15 | 0 hypotheses

Are age-related static epigenetic patterns pathogenic or protective compensatory

epigenetics | 2026-04-15 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
TREM2, microglia, and Alzheimer's disease. [PMID:33516818]	Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang	Mech Ageing Dev	2021	1
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797]	Zhou Y, Song WM, Andhey PS, Swain A, Lev	Nat Med	2020	1
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038]	Ulland TK, Song WM, Huang SC, Ulrich JD,	Cell	2017	1
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663]	Krasemann S, Madore C, Cialic R, Baufeld	Immunity	2017	1
Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and T [PMID:41833042]	["Lyu G", "Li D"]	CNS & neurological disorders d	2026	0
Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuro [PMID:41858793]	["Wang R", "Feng Y", "Zhou Z", "Jiang J"	Frontiers in aging neuroscienc	2026	0
Human CSF proteogenomics links genetic variation to neurodegenerative disease pr [PMID:41757182]	["Puerta R", "Garc\u00eda-Gonz\u00e1lez	medRxiv : the preprint server	2026	0
PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907]	Tsai AP, Martin AK, Mi A, Yeh AE, Ramire	Molecular neurodegeneration	2026	0
TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604]	Yang HC, Deng YS, Zhang J, Zhang T, Song	J Alzheimers Dis	2026	0
A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated [PMID:41957412]	Villani A, Wittmann J, Wyss T, Mallona I	Commun Biol	2026	0
Dual Role of Microglial TREM2 in Neuronal Degeneration and Regeneration After Ax [PMID:41963086]	Pottorf TS, Lane EL, Haley-Johnson Z, Uk	J Neurosci	2026	0
TREM2-mediated microglial phagocytosis of inhibitory synapses contributes to pro [PMID:41965330]	Wang X, Zhou H, Zhai Y, Zhang Y, Cheng Y	Cell Death Discov	2026	0
Investigating the Potential of Gene Editing Technologies in Enhancing Stem Cell [PMID:41926312]	["Mehrabadi S"]	Current aging science	2026	0
TREM2 in neurodegeneration and diseases. [PMID:41792456]	["Abdulkhaliq A", "Alasiri G", "Kim B",	Molecular psychiatry	2026	0
Berbamine hydrochloride as a brain penetrant galectin 3 inhibitor in a model of [PMID:41772384]	["Siew J", "Lee C", "Chen H", "Lin H", "	Brain : a journal of neurology	2026	0
The microglial TREM2 receptor programs hippocampal development in a mouse model [PMID:41887542]	Ahmed S, Bowers C, Munoz-Martin J, Jamwa	Brain, behavior, and immunity	2026	0
Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842]	Alhusaini M, Mussa BM, Ilce BY, Alhaj H,	Frontiers in aging neuroscienc	2026	0

RA

Understanding Entity Pages

Summary

Wiki Pages (21)

RA Capital Management

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Novel Therapy Index

CBS/PSP Supplements Guide

Device Therapies Comparison for CBS/PSP

Alpha-Synuclein Pathology

nhp-validation-animal-model

NTF4 Protein

TREM2 Mechanism Hub

HNRNPA2B1 Protein

Growth Factor Therapies

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms

Neurotrophin Signaling Pathways in Neurodegeneration

dendritic-spines

omega-3-fatty-acids-neurodegeneration

AI and Machine Learning in Neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

VEGF/Angiogenesis Pathway in Neurodegeneration

Coenzyme Q10 for Neurodegeneration

Pathway Diagram

Outgoing (0)

Incoming (158)

Targeting Hypotheses (30)

Mentioning Analyses (30)

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

What are the specific molecular determinants that govern tau strain selection du

What are the cell-type-specific transcriptomic signatures of vulnerability in SE

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

Are age-related static epigenetic patterns pathogenic or protective compensatory

What determines the GPX4/ACSL4 balance that switches microglia from protective t

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

What is the temporal sequence of TREM2 signaling transition from protective to i

Are interneuron oscillation deficits compensatory responses or primary pathologi

Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in agin

What are the precise temporal dynamics of astrocyte ketone production decline du

Should microtubule-stabilizing drugs be reconsidered as therapeutic targets for

How does engineered C. butyricum cross the blood-brain barrier to directly bind

What are the physiological functions of BACE1 beyond APP processing that could c

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

What upstream mechanisms trigger p53 activation specifically in response to poly

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

What molecular mechanisms drive the transition from acute to persistent neuroinf

Why does autophagy inhibition improve neuronal survival when autophagy is typica

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

Does clusterin exacerbate or protect against neuronal death in neurodegeneration

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

Related Papers (20)