Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RIG-I: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | RIG |
| Function | Rig I Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Subcellular Localization | to Cytoplasm and plays a significant role in the pathogenesis of [Alzheimer's Di |
| GeneCards | RIG |
| Human Protein Atlas | RIG |
| Interactions | STING, TBK1, WAS |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
RIG_I(["RIG-I"])
FUS(["FUS"])
STING(["STING"])
TBK1(["TBK1"])
WAS(["WAS"])
Neuron["/"Neuron"/"]
NEURON(["NEURON"])
Neurodegeneration["Neurodegeneration"]
FUS -->|"upstream of"| RIG_I
RIG_I -->|"activates"| STING
RIG_I -->|"activates"| TBK1
RIG_I -->|"activates"| WAS
RIG_I -->|"activates"| Neuron
NEURON -->|"co discussed"| RIG_I
Neurodegeneration -->|"activates"| RIG_I
style RIG_I fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | regulates | disease | 0.55 |
| neuroinflammation | regulates | disease | 0.55 |
| oxidative stress response | participates_in | pathway | 0.55 |
| STING | activates | gene | 0.50 |
| TBK1 | activates | gene | 0.50 |
| WAS | activates | protein | 0.50 |
| Neuron | activates | cell_type | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FUS | upstream_of | protein | 0.60 |
| NEURON | co_discussed | gene | 0.50 |
| Neurodegeneration | activates | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||