| Gene Symbol | TBK1 |
| Full Name | TANK Binding Kinase 1 |
| Chromosome | 12q14.2 |
| Protein Type | Serine/Threonine Kinase |
| Function | TBK1 belongs to the IκB kinase (IKK) subfamily of kinases, originally characterized for its role in activating innate immune signaling through the induction of type I interferons in response to viral |
| Primary Expression | Motor cortex, Spinal cord, Immune cells |
| Molecular Weight | 84 kDa |
| Pathways | Apoptosis, Autophagy, Epigenetic, Er Stress, Immune Response |
| UniProt ID | Q9UHD2 |
| NCBI Gene ID | 29110 |
| Ensembl ID | ENSG00000183735 |
| OMIM | 604834 |
| GeneCards | TBK1 |
| Human Protein Atlas | TBK1 |
| Mutation Type | Effect |
| Associated Diseases | ALS, AUTOPHAGY, AXONAL DEGENERATION, Aging, Alzheimer |
| Known Drugs/Compounds | amlexanox, rapamycin |
| Interactions | CHMP2B, OVERVIEW, VALOSIN, MTOR, NDP52, FIP200 |
| SciDEX Hypotheses | TBK1 Loss-of-Function Amplifies C1q-Mediated Synap |
| KG Connections | 1327 knowledge graph edges |
| Databases | GeneCardsHPASTRING |