| Gene Symbol | TBK1 |
| Full Name | Mediated Neuroinflammation Hypothesis: Autophagy Failure Drives FTD/ALS |
| Chromosome | 12q14.2 |
| Protein Type | Serine/Threonine Kinase |
| Function | TBK1 belongs to the IκB kinase (IKK) subfamily of kinases, originally characterized for its role in activating innate immune signaling through the induction of type I interferons in response to viral |
| Primary Expression | Motor cortex, Spinal cord, Immune cells |
| Molecular Weight | 84 kDa |
| Pathways | Apoptosis, Autophagy, Epigenetic, Er Stress, Immune Response |
| UniProt ID | Q9UHD2 |
| NCBI Gene ID | 29110 |
| Ensembl ID | ENSG00000183735 |
| OMIM | 604834 |
| GeneCards | TBK1 |
| Human Protein Atlas | TBK1 |
| Associated Diseases | Aging, als, ALS/FTD, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | amlexanox, rapamycin |
| Interactions | Actin, AGING, AIM2, AKT, AKT1, ALS |
| SciDEX Hypotheses | TBK1-OPTN-p62 selective autophagy failure across A TBK1 Loss-of-Function Amplifies C1q-Mediated Synap Microglial TBK1 Deficiency Triggers Senescence-Ass (+4 more) |
| KG Connections | 1302 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!