gene 1,287 words KG: TRAF3 2026-03-28
kind:genesection:genesstate:published
Contents

TRAF3

🧬 Gene Info
Gene SymbolTRAF3
Full NameTNF Receptor-Associated Factor 3
AliasesCAP-1, CAP1, RNF83
Chromosome4p12
Protein TypeReceptor
Functionis a crucial signaling adapter protein that regulates multiple innate immune signaling pathways, including NF-κB, MAPK, and type I interferon responses.
Gene TypeProtein Coding
PathwaysNF-κB, nfkb, MAPK, NF-κB Signaling
UniProt IDQ9Y4K0
NCBI Gene ID7188
Ensembl IDENSG00000126777
GeneCardsTRAF3
Human Protein AtlasTRAF3
Associated DiseasesAls, Tumor
InteractionsTLR4, CAT, UBIQUITIN, LC3, TLR, INFLAMMATION
KG Connections58 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
Exercise-BDNF-Mitophagy Biomarker Study in PD
clinical · proposed · Score: 0.40
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · proposed · Score: 0.40
NLRP3 Inflammasome Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Tau ASO Therapy
validation · proposed · Score: 0.40

See Also (15)

MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
NLRP3 Inflammasome Hypothesis in Parkinson's Disease
hypothesis · KG edge: regulates
PDE4B — Phosphodiesterase 4B
gene · KG edge: regulates
NOD2 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TRAF3 inhibits TLR4
TRAF3 inhibits CAT
TRAF3 inhibits UBIQUITIN
TRAF3 regulates TRAF6
TRAF3 regulates NDP52
TRAF3 inhibits LC3
TRAF3 regulates UBIQUITIN
TRAF3 inhibits Inflammation
TRAF3 activates Diabetes
TRAF3 associated_with Tumor