gene 1,373 words KG: NLRC3
Contents

NLRC3 — NLR Family CARD Domain Containing 3

🧬 Gene Info
Gene SymbolNLRC3
Full NameNLR Family CARD Domain Containing 3
Chromosome16p13.3
Protein TypeReceptor
Functionis a member of the NOD-like receptor (NLR) family of proteins.
Primary Expressionvarious tissues, with highest expression in immune cells and epithelial tissues
Molecular Weight85 kDa
Amino Acids755 aa
Exons14
PathwaysNf-Κb
UniProt IDQ7RTV0
NCBI Gene ID81128
Ensembl IDENSG00000167900
OMIM611362
GeneCardsNLRC3
Human Protein AtlasNLRC3
Associated DiseasesMs
InteractionsTNF, NLRP3, STAT3, TLR4, TRAF6, INFLAMMATION
KG Connections22 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
LRP1-Dependent Tau Uptake Disruption
Score: 0.44

Related Analyses (2)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Adaptive Immunity in Neurodegeneration
mechanism · KG edge: inhibits
TRAF6 Gene
gene · KG edge: regulates
TNF (Redirect)
redirect · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates

Knowledge Graph (12 edges)

NLRC3 activates TNF
NLRC3 regulates TRAF6
NLRC3 activates NLRP3
NLRC3 activates STAT3
NLRC3 activates TLR4
NLRC3 activates TRAF6
NLRC3 inhibits INFLAMMATION
NLRC3 regulates NF-ΚB
NLRC3 activates APOPTOSIS
NLRC3 activates TNF-Α