Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SESN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SESN3 |
| Full Name | Sestrin 3 |
| Chromosome | 11q21<br> |
| Function | SESN3 shares functional similarities with other sestrins (SESN1 and SESN2): |
| Primary Expression | various tissues: - Brain: cortex, hippocampus, cerebellum - Liver, kidney, muscle - Inducible b |
| Molecular Weight | 49 kDa |
| Pathways | signaling: - AMPK senses cellular energy status, mTOR, AMPK, AMPK signaling |
| UniProt ID | Q9Y5P4 |
| NCBI Gene ID | 286826 |
| Ensembl ID | ENSG00000148231 |
| GeneCards | SESN3 |
| Human Protein Atlas | SESN3 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Metabolic Disease |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SESN3["SESN3"]
SESN3 -->|"expressed in"| Ms["Ms"]
SESN3 -->|"expressed in"| Als["Als"]
SESN3 -->|"expressed in"| ATG7["ATG7"]
SESN3 -->|"expressed in"| CSF1R["CSF1R"]
SESN3 -->|"expressed in"| AND["AND"]
SESN3 -->|"expressed in"| MICROGLIA["MICROGLIA"]
SESN3 -->|"expressed in"| LGALS1["LGALS1"]
SESN3 -->|"expressed in"| GPNMB["GPNMB"]
LGALS3["LGALS3"] -->|"expressed in"| SESN3
CD44["CD44"] -->|"expressed in"| SESN3| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| ATG7 | expressed_in | gene | 0.60 |
| CSF1R | expressed_in | gene | 0.60 |
| LGALS1 | expressed_in | gene | 0.60 |
| GPNMB | expressed_in | gene | 0.60 |
| GAIN | expressed_in | gene | 0.60 |
| LGALS3 | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| MICROGLIA | expressed_in | gene | 0.60 |
| RNA | expressed_in | gene | 0.60 |
| White Matter | expressed_in | brain_region | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||